Background: Over the years, forensic pathology has registered the spread of new methods of suicide, such as the ingestion of sodium nitrite. Sodium nitrite causes increased methemoglobin, resulting in systemic hypoxia, metabolic acidosis, and cyanosis. Since sodium nitrite is a preservative, the ingestion of foods containing an excessive amount of this substance can also cause acute intoxication up to death. The present review is aimed at guiding health professionals in the identification and management of sodium-nitrite-related intoxications and deaths. Methods: A systematic literature search was carried out on PubMed by following the PRISMA statement's criteria. A total of 35 studies with 132 cases were enrolled, and the data were cataloged in Microsoft Excel. To establish the causal correlation between sodium nitrite ingestion and death, the Naranjo Adverse Drug Reaction Probability Scale was used. Results: In addition to the small number of cases that have currently been published, the study demonstrated that there was a general methodological discrepancy in the diagnostic process. However, some interesting results have emerged, especially in post-mortem diagnostics. Conclusion: Sodium-nitrite-related deaths represent a challenge for forensic pathologists; therefore, it is important to promptly recognize the essential features and perform the necessary and unrepeatable examinations for the correct diagnosis of the cause of death.

Sodium nitrite intoxication and death. Summarizing evidence to faciliate diagnosis / Padovano, Martina; Aromatario, Mariarosaria; D'Errico, Stefano; Concato, Monica; Manetti, Federico; David, Maria Chiara; Scopetti, Matteo; Frati, Paola; Fineschi, Vittorio. - In: INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH. - ISSN 1660-4601. - 19:21(2022), pp. 1-16. [10.3390/ijerph192113996]

Sodium nitrite intoxication and death. Summarizing evidence to faciliate diagnosis

Padovano, Martina;Aromatario, Mariarosaria;Manetti, Federico;David, Maria Chiara;Scopetti, Matteo;Frati, Paola;Fineschi, Vittorio
2022

Abstract

Background: Over the years, forensic pathology has registered the spread of new methods of suicide, such as the ingestion of sodium nitrite. Sodium nitrite causes increased methemoglobin, resulting in systemic hypoxia, metabolic acidosis, and cyanosis. Since sodium nitrite is a preservative, the ingestion of foods containing an excessive amount of this substance can also cause acute intoxication up to death. The present review is aimed at guiding health professionals in the identification and management of sodium-nitrite-related intoxications and deaths. Methods: A systematic literature search was carried out on PubMed by following the PRISMA statement's criteria. A total of 35 studies with 132 cases were enrolled, and the data were cataloged in Microsoft Excel. To establish the causal correlation between sodium nitrite ingestion and death, the Naranjo Adverse Drug Reaction Probability Scale was used. Results: In addition to the small number of cases that have currently been published, the study demonstrated that there was a general methodological discrepancy in the diagnostic process. However, some interesting results have emerged, especially in post-mortem diagnostics. Conclusion: Sodium-nitrite-related deaths represent a challenge for forensic pathologists; therefore, it is important to promptly recognize the essential features and perform the necessary and unrepeatable examinations for the correct diagnosis of the cause of death.
2022
autopsy findings; fatal methemoglobinemia; forensic pathology; post-mortem investigations; post-mortem toxicology; sodium nitrite; suicide
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
Sodium nitrite intoxication and death. Summarizing evidence to faciliate diagnosis / Padovano, Martina; Aromatario, Mariarosaria; D'Errico, Stefano; Concato, Monica; Manetti, Federico; David, Maria Chiara; Scopetti, Matteo; Frati, Paola; Fineschi, Vittorio. - In: INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH. - ISSN 1660-4601. - 19:21(2022), pp. 1-16. [10.3390/ijerph192113996]
File allegati a questo prodotto
File Dimensione Formato  
Padovano_Sodium_2022.pdf

accesso aperto

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Creative commons
Dimensione 2.27 MB
Formato Adobe PDF
2.27 MB Adobe PDF

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1677041
Citazioni
  • ???jsp.display-item.citation.pmc??? 1
  • Scopus 5
  • ???jsp.display-item.citation.isi??? 2
social impact