In this work, several eutectic mixtures formed by fenchol and acetic acid at seven molar ratios (between 4:1 and 1:4) were characterized and studied for the first time for their possible application as extraction solvents in dispersive liquid-liquid microextraction based on the solidification of the floating organic droplet (DLLME-SFO). A group of 13 emerging contaminants (gemfibrozil, bisphenol F, bisphenol A, 17β-estradiol, testosterone, estrone, levonorgestrel, 4-tert-octylphenol, butyl benzyl phthalate, dibutyl phthalate, 4-octylphenol, 4-nonylphenol, and dihexyl phthalate) was selected and determined by liquid chromatography with ultraviolet and tandem mass spectrometry detection. Among the studied mixtures, only those of 2:1 and 1:1 provided the suitable features from an operational and repeatability point of view, suggesting that several eutectic mixtures of the same components may also provide similar results. Once the extraction conditions of both mixtures were optimized, the method was applied to the extraction of sea water, urine, and wastewater at different concentration levels, allowing the achievement of absolute recovery values between 49 and 100% for most analytes with relative standard deviation values below 19%. In addition, several samples of each type were analyzed, finding bisphenol A and gemfibrozil in some of them. The greenness of the method was also evaluated using the AGREEprep metric. The DLLME-SFO procedure was found to be very simple, quick, and effective and with a good sample throughput.

Extraction of emerging contaminants from environmental waters and urine by dispersive liquid-liquid microextraction with solidification of the floating organic droplet using fenchol:acetic acid deep eutectic mixtures / Ortega-Zamora, C.; Jimenez-Skrzypek, G.; Gonzalez-Salamo, J.; Mazzapioda, L.; Navarra, M. A.; Gentili, A.; Hernandez-Borges, J.. - In: ACS SUSTAINABLE CHEMISTRY & ENGINEERING. - ISSN 2168-0485. - 10:48(2022), pp. 15714-15725. [10.1021/acssuschemeng.2c04044]

Extraction of emerging contaminants from environmental waters and urine by dispersive liquid-liquid microextraction with solidification of the floating organic droplet using fenchol:acetic acid deep eutectic mixtures

Mazzapioda L.;Navarra M. A.;Gentili A.;
2022

Abstract

In this work, several eutectic mixtures formed by fenchol and acetic acid at seven molar ratios (between 4:1 and 1:4) were characterized and studied for the first time for their possible application as extraction solvents in dispersive liquid-liquid microextraction based on the solidification of the floating organic droplet (DLLME-SFO). A group of 13 emerging contaminants (gemfibrozil, bisphenol F, bisphenol A, 17β-estradiol, testosterone, estrone, levonorgestrel, 4-tert-octylphenol, butyl benzyl phthalate, dibutyl phthalate, 4-octylphenol, 4-nonylphenol, and dihexyl phthalate) was selected and determined by liquid chromatography with ultraviolet and tandem mass spectrometry detection. Among the studied mixtures, only those of 2:1 and 1:1 provided the suitable features from an operational and repeatability point of view, suggesting that several eutectic mixtures of the same components may also provide similar results. Once the extraction conditions of both mixtures were optimized, the method was applied to the extraction of sea water, urine, and wastewater at different concentration levels, allowing the achievement of absolute recovery values between 49 and 100% for most analytes with relative standard deviation values below 19%. In addition, several samples of each type were analyzed, finding bisphenol A and gemfibrozil in some of them. The greenness of the method was also evaluated using the AGREEprep metric. The DLLME-SFO procedure was found to be very simple, quick, and effective and with a good sample throughput.
2022
dispersive liquid-liquid microextraction based on the solidification of the floating organic droplet; emerging contaminants; fenchol; high-performance liquid chromatography; mass spectrometry; natural deep eutectic solvents
01 Pubblicazione su rivista::01a Articolo in rivista
Extraction of emerging contaminants from environmental waters and urine by dispersive liquid-liquid microextraction with solidification of the floating organic droplet using fenchol:acetic acid deep eutectic mixtures / Ortega-Zamora, C.; Jimenez-Skrzypek, G.; Gonzalez-Salamo, J.; Mazzapioda, L.; Navarra, M. A.; Gentili, A.; Hernandez-Borges, J.. - In: ACS SUSTAINABLE CHEMISTRY & ENGINEERING. - ISSN 2168-0485. - 10:48(2022), pp. 15714-15725. [10.1021/acssuschemeng.2c04044]
File allegati a questo prodotto
File Dimensione Formato  
Ortega-Zamora_Extraction of Emerging Contaminants_2022.pdf

accesso aperto

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 2.9 MB
Formato Adobe PDF
2.9 MB Adobe PDF

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1676464
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 8
  • ???jsp.display-item.citation.isi??? 6
social impact