Brain metastases are common complications that occur in 10–50% of patients with cancer, representing a major challenge in oncology. Historically, whole brain radiotherapy (WBRT) has been the mainstay of treatment; however, treatment has been rapidly evolving due to new radiotherapy technologies and systemic therapies changing the treatment framework for several cancers. Prospective randomised studies have shown significantly higher efficacy of stereotactic radiosurgery (SRS) in reducing the detrimental effects of cognitive function and quality of life associated with WBRT while maintaining equivalent survival benefit. So far, SRS has become the standard of care for patients with one to four brain metastases.

Should radiotherapy be considered for the initial treatment of brain metastases? / Minniti, G.; Le Rhun, E.. - In: THE LANCET ONCOLOGY. - ISSN 1470-2045. - 23:2(2022), pp. 205-206. [10.1016/S1470-2045(21)00696-3]

Should radiotherapy be considered for the initial treatment of brain metastases?

Minniti G.
Primo
Writing – Review & Editing
;
2022

Abstract

Brain metastases are common complications that occur in 10–50% of patients with cancer, representing a major challenge in oncology. Historically, whole brain radiotherapy (WBRT) has been the mainstay of treatment; however, treatment has been rapidly evolving due to new radiotherapy technologies and systemic therapies changing the treatment framework for several cancers. Prospective randomised studies have shown significantly higher efficacy of stereotactic radiosurgery (SRS) in reducing the detrimental effects of cognitive function and quality of life associated with WBRT while maintaining equivalent survival benefit. So far, SRS has become the standard of care for patients with one to four brain metastases.
2022
brain metastases; radiotherapy; cancer immunotherapy; human; overall survival; patient care; progression free survival; prospective study; quality of life
01 Pubblicazione su rivista::01m Editorial/Introduzione in rivista
Should radiotherapy be considered for the initial treatment of brain metastases? / Minniti, G.; Le Rhun, E.. - In: THE LANCET ONCOLOGY. - ISSN 1470-2045. - 23:2(2022), pp. 205-206. [10.1016/S1470-2045(21)00696-3]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1676376
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