The differentiation between radiation-induced changes and tumor recurrence is a major pitfall of magnetic resonance imaging, which can be overcome by the use of PET. Although amino-acid PET tracers showed several advantages over 18F-fluorodeoxyglucose in neurooncology, studies comparing these 2 types of radiopharmaceuticals in previously irradiated brain metastases are lacking. Here, we demonstrated a mismatch between 3,4-dihydroxy-6-[18F]-fluoro-l-phenylalanine (F-DOPA) and FDG in the first report of a previously irradiated brain metastasis undergoing a longitudinal evaluation by sequential double tracer PET imaging.
Metabolic Evolution of Brain Metastasis after Stereotactic Radiosurgery: Mismatch between F-DOPA and FDG PET / Cicone, F.; Carideo, L.; Villani, V.; Scaringi, C.; Bozzao, A.; Scopinaro, F.; Minniti, G.. - In: CLINICAL NUCLEAR MEDICINE. - ISSN 0363-9762. - 45:7(2020), pp. 557-558. [10.1097/RLU.0000000000003070]
Metabolic Evolution of Brain Metastasis after Stereotactic Radiosurgery: Mismatch between F-DOPA and FDG PET
Minniti G.
2020
Abstract
The differentiation between radiation-induced changes and tumor recurrence is a major pitfall of magnetic resonance imaging, which can be overcome by the use of PET. Although amino-acid PET tracers showed several advantages over 18F-fluorodeoxyglucose in neurooncology, studies comparing these 2 types of radiopharmaceuticals in previously irradiated brain metastases are lacking. Here, we demonstrated a mismatch between 3,4-dihydroxy-6-[18F]-fluoro-l-phenylalanine (F-DOPA) and FDG in the first report of a previously irradiated brain metastasis undergoing a longitudinal evaluation by sequential double tracer PET imaging.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
