Background/Aim: The aim of this study was to investigate the treatment outcomes and toxicities in patients with liver disease treated by Stereotactic Body Radiation Therapy (SBRT). Patients and Methods: From 2007 to 2016, 43 patients with 58 lesions (6 primary and 37 metastatic liver tumors) were treated with SBRT. Results: Local Control was reached in 47 out of 58 (81%) treated lesions with 12 and 24-month rates of 81% and 74% respectively. The progression-free survival at 12 and 24 months was 42% and 36%, respectively. The disease specific survival at 12 and 24 months was 74% and 46% respectively. Median overall survival (OS) was 20 months and the rates of OS were 74% and 46% at 12 and 24 months respectively. Toxicity was very low consisting mainly of Grade 1 and 2. Conclusion: SBRT provides good local control for both primary and metastatic liver lesions, with minimal toxicity.
Stereotactic body radiation therapy in primary and metastatic liver disease / Caivano, D.; Valeriani, M.; Russo, I.; Bonome, P.; De Matteis, S.; Minniti, G.; Falchetto Osti, M.. - In: ANTICANCER RESEARCH. - ISSN 0250-7005. - 37:12(2017), pp. 7005-7010. [10.21873/anticanres.12169]
Stereotactic body radiation therapy in primary and metastatic liver disease
Caivano D.
Primo
;Minniti G.Penultimo
;Falchetto Osti M.Ultimo
2017
Abstract
Background/Aim: The aim of this study was to investigate the treatment outcomes and toxicities in patients with liver disease treated by Stereotactic Body Radiation Therapy (SBRT). Patients and Methods: From 2007 to 2016, 43 patients with 58 lesions (6 primary and 37 metastatic liver tumors) were treated with SBRT. Results: Local Control was reached in 47 out of 58 (81%) treated lesions with 12 and 24-month rates of 81% and 74% respectively. The progression-free survival at 12 and 24 months was 42% and 36%, respectively. The disease specific survival at 12 and 24 months was 74% and 46% respectively. Median overall survival (OS) was 20 months and the rates of OS were 74% and 46% at 12 and 24 months respectively. Toxicity was very low consisting mainly of Grade 1 and 2. Conclusion: SBRT provides good local control for both primary and metastatic liver lesions, with minimal toxicity.| File | Dimensione | Formato | |
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