More recently, significant advances have been made in the understanding of the molecular pathogenesis of gliomas. For example, isocitrate dehydrogenase (IDH) mutation is a defining event in glioma development, appearing early in gliomagenesis and giving rise to gliomas with distinct behavior. Mutations in IDH, a rate-limiting enzyme in the Krebs cycle, likely affect metabolic activity and genetic expression.
The IMPACT of molecular grading of gliomas on contemporary clinical practice / Milano, M. T.; Chan, M. D.; Minniti, G.; Hattangadi-Gluth, J. A.; Redmond, K. J.; Soltys, S. G.. - In: INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS. - ISSN 0360-3016. - 107:5(2020), pp. 859-862. [10.1016/j.ijrobp.2020.05.043]
The IMPACT of molecular grading of gliomas on contemporary clinical practice
Minniti G.;
2020
Abstract
More recently, significant advances have been made in the understanding of the molecular pathogenesis of gliomas. For example, isocitrate dehydrogenase (IDH) mutation is a defining event in glioma development, appearing early in gliomagenesis and giving rise to gliomas with distinct behavior. Mutations in IDH, a rate-limiting enzyme in the Krebs cycle, likely affect metabolic activity and genetic expression.| File | Dimensione | Formato | |
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