Parkinson’s disease is the second most common neurodegenerative disorder, affecting 2–3% of the population of patients >65 years. Although the standard diagnosis of PD is clinical, neuroimaging plays a key role in the evaluation of patients who present symptoms related to neurodegenerative disorders. MRI, DAT-SPECT, and PET with [18F]-FDG are routinely used in the diagnosis and focus on the investigation of morphological changes, nigrostriatal degeneration or shifts in glucose metabolism in patients with parkinsonian syndromes. The aim of this study is to review the current PET radiotracers targeting TSPO, a transmembrane protein that is overexpressed by microglia in another pathophysiological process associated with neurodegenerative disorders known as neuroinflammation. To the best of our knowledge, neuroinflammation is present not only in PD but in many other neurodegenerative disorders, including AD, DLB, and MSA, as well as atypical parkinsonian syndromes. Therefore, in this study, specific patterns of microglial activation in PD and the differences in distribution volumes of these radiotracers in patients with PD as compared to other neurodegenerative disorders are reviewed.

PET imaging of neuro-inflammation with tracers targeting the translocator protein (TSPO), a systematic review: from bench to bedside / Corica, Ferdinando; De Feo, Maria Silvia; Gorica, Joana; Sidrak, Marko Magdi Abdou; Conte, Miriam; Filippi, Luca; Schillaci, Orazio; De Vincentis, Giuseppe; Frantellizzi, Viviana. - In: DIAGNOSTICS. - ISSN 2075-4418. - 13:6(2023). [10.3390/diagnostics13061029]

PET imaging of neuro-inflammation with tracers targeting the translocator protein (TSPO), a systematic review: from bench to bedside

Corica, Ferdinando
Primo
;
De Feo, Maria Silvia
Secondo
;
Gorica, Joana;Sidrak, Marko Magdi Abdou;Conte, Miriam;De Vincentis, Giuseppe
Penultimo
;
Frantellizzi, Viviana
Ultimo
2023

Abstract

Parkinson’s disease is the second most common neurodegenerative disorder, affecting 2–3% of the population of patients >65 years. Although the standard diagnosis of PD is clinical, neuroimaging plays a key role in the evaluation of patients who present symptoms related to neurodegenerative disorders. MRI, DAT-SPECT, and PET with [18F]-FDG are routinely used in the diagnosis and focus on the investigation of morphological changes, nigrostriatal degeneration or shifts in glucose metabolism in patients with parkinsonian syndromes. The aim of this study is to review the current PET radiotracers targeting TSPO, a transmembrane protein that is overexpressed by microglia in another pathophysiological process associated with neurodegenerative disorders known as neuroinflammation. To the best of our knowledge, neuroinflammation is present not only in PD but in many other neurodegenerative disorders, including AD, DLB, and MSA, as well as atypical parkinsonian syndromes. Therefore, in this study, specific patterns of microglial activation in PD and the differences in distribution volumes of these radiotracers in patients with PD as compared to other neurodegenerative disorders are reviewed.
2023
TSPO; translocator protein; PET; neuro-inflammation; peripheral benzodiazepine receptor
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
PET imaging of neuro-inflammation with tracers targeting the translocator protein (TSPO), a systematic review: from bench to bedside / Corica, Ferdinando; De Feo, Maria Silvia; Gorica, Joana; Sidrak, Marko Magdi Abdou; Conte, Miriam; Filippi, Luca; Schillaci, Orazio; De Vincentis, Giuseppe; Frantellizzi, Viviana. - In: DIAGNOSTICS. - ISSN 2075-4418. - 13:6(2023). [10.3390/diagnostics13061029]
File allegati a questo prodotto
File Dimensione Formato  
Corica_PET-Imaging_2023.pdf

accesso aperto

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Creative commons
Dimensione 357.72 kB
Formato Adobe PDF
357.72 kB Adobe PDF

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1676192
Citazioni
  • ???jsp.display-item.citation.pmc??? 3
  • Scopus 11
  • ???jsp.display-item.citation.isi??? 9
social impact