Objective Fractional extracellular space has been validated as a marker of hepatic fibrotic in cirrhotic patients at CT-scan as well as on dual-energy CT, which takes advantage from iodine uptake. Since no consensus still exists between equilibrium phases performed at 3 or 10 min, the first aim of this work is to evaluate performances at the two different time points. Moreover, correlation between fractional extracellular space and oesophageal varices, directly related to liver fibrosis, has been assessed. Materials and methods Dual-Energy equilibrium phases at 3 and 10 min were performed within a follow-up CT-protocol scan in cirrhotic patients. Oesophageal varices were endoscopically assessed according to their size. At the two different time points, correlation between iodine density of the right and left liver lobes and correlation between the fractional extracellular space values were assessed. Correlation between fractional extracellular space and endoscopic grade of oesophageal varices was calculated. Results No statistical differences were found between the iodine density values from the two liver lobes at the two time points (p = 0.8 at 3 '; p = 0.5 at 10 '). No statistical difference about fractional extracellular space estimation was found between the two time points (p = 0.17). Correlation between fractional extracellular space values and oesophageal varices was moderate (rho = 0.45, IC 0.08-0.71, p < 0.05). Conclusion Fractional extracellular space assessed on dual-energy CT at equilibrium phases with different timing was substantially similar. The moderate correlation found between fractional extracellular space and endoscopic grade of oesophageal varices confirms that CT-scan is not currently reliable as endoscopy.

Dual-energy CT quantification of fractional extracellular space in cirrhotic patients: comparison between early and delayed equilibrium phases and correlation with oesophageal varices / Cicero, Giuseppe; Mazziotti, Silvio; Silipigni, Salvatore; Blandino, Alfredo; Cantisani, Vito; Pergolizzi, Stefano; D'Angelo, Tommaso; Stagno, Alberto; Maimone, Sergio; Squadrito, Giovanni; Ascenti, Giorgio. - In: LA RADIOLOGIA MEDICA. - ISSN 0033-8362. - 126:6(2021), pp. 761-767. [10.1007/s11547-021-01341-z]

Dual-energy CT quantification of fractional extracellular space in cirrhotic patients: comparison between early and delayed equilibrium phases and correlation with oesophageal varices

Cantisani, Vito;
2021

Abstract

Objective Fractional extracellular space has been validated as a marker of hepatic fibrotic in cirrhotic patients at CT-scan as well as on dual-energy CT, which takes advantage from iodine uptake. Since no consensus still exists between equilibrium phases performed at 3 or 10 min, the first aim of this work is to evaluate performances at the two different time points. Moreover, correlation between fractional extracellular space and oesophageal varices, directly related to liver fibrosis, has been assessed. Materials and methods Dual-Energy equilibrium phases at 3 and 10 min were performed within a follow-up CT-protocol scan in cirrhotic patients. Oesophageal varices were endoscopically assessed according to their size. At the two different time points, correlation between iodine density of the right and left liver lobes and correlation between the fractional extracellular space values were assessed. Correlation between fractional extracellular space and endoscopic grade of oesophageal varices was calculated. Results No statistical differences were found between the iodine density values from the two liver lobes at the two time points (p = 0.8 at 3 '; p = 0.5 at 10 '). No statistical difference about fractional extracellular space estimation was found between the two time points (p = 0.17). Correlation between fractional extracellular space values and oesophageal varices was moderate (rho = 0.45, IC 0.08-0.71, p < 0.05). Conclusion Fractional extracellular space assessed on dual-energy CT at equilibrium phases with different timing was substantially similar. The moderate correlation found between fractional extracellular space and endoscopic grade of oesophageal varices confirms that CT-scan is not currently reliable as endoscopy.
2021
dual-energy CT; fractional extracellular space; liver cirrhosis
01 Pubblicazione su rivista::01a Articolo in rivista
Dual-energy CT quantification of fractional extracellular space in cirrhotic patients: comparison between early and delayed equilibrium phases and correlation with oesophageal varices / Cicero, Giuseppe; Mazziotti, Silvio; Silipigni, Salvatore; Blandino, Alfredo; Cantisani, Vito; Pergolizzi, Stefano; D'Angelo, Tommaso; Stagno, Alberto; Maimone, Sergio; Squadrito, Giovanni; Ascenti, Giorgio. - In: LA RADIOLOGIA MEDICA. - ISSN 0033-8362. - 126:6(2021), pp. 761-767. [10.1007/s11547-021-01341-z]
File allegati a questo prodotto
File Dimensione Formato  
Cicero_Dual‑energy CT_2021.pdf

solo gestori archivio

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 1.33 MB
Formato Adobe PDF
1.33 MB Adobe PDF   Contatta l'autore

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1675937
Citazioni
  • ???jsp.display-item.citation.pmc??? 19
  • Scopus 37
  • ???jsp.display-item.citation.isi??? 35
social impact