Acne is a common and complex skin disease, with a very complex pathogenesis. Although in women the relationship between acne and insulin resistance is well known, in particular in women with PCOS, in males this relationship has been poorly investigated. In total, 20 subjects with an altered metabolic profile were considered for this study and randomized as follows: 10 patients were treated with metformin plus a hypocaloric diet for 6months (group A), while 10 patients did not receive any treatment with metformin and were only followed up (group B). All patients of group A, after 6 months of metformin therapy, had a statistically significant improvement compared with patients in group B. Our study reveals the importance of diet and insulin resistance in acne pathogenesis, and underlines the possible use of metformin and diet as possible adjuvant therapy for male patients with acne.

Low glycaemic diet and metformin therapy. a new approach in male subjects with acne resistant to common treatments / Fabbrocini, G; Izzo, R; Faggiano, A; Del Prete, M; Donnarumma, M; Marasca, C; Marciello, F; Savastano, R; Monfrecola, G; Colao, A. - In: CLINICAL AND EXPERIMENTAL DERMATOLOGY. - ISSN 0307-6938. - 41:1(2016), pp. 38-42. [10.1111/ced.12673]

Low glycaemic diet and metformin therapy. a new approach in male subjects with acne resistant to common treatments

Faggiano, A;Del Prete, M;Donnarumma, M;Marasca, C;
2016

Abstract

Acne is a common and complex skin disease, with a very complex pathogenesis. Although in women the relationship between acne and insulin resistance is well known, in particular in women with PCOS, in males this relationship has been poorly investigated. In total, 20 subjects with an altered metabolic profile were considered for this study and randomized as follows: 10 patients were treated with metformin plus a hypocaloric diet for 6months (group A), while 10 patients did not receive any treatment with metformin and were only followed up (group B). All patients of group A, after 6 months of metformin therapy, had a statistically significant improvement compared with patients in group B. Our study reveals the importance of diet and insulin resistance in acne pathogenesis, and underlines the possible use of metformin and diet as possible adjuvant therapy for male patients with acne.
2016
acne; metformin; low glycaemic diet
01 Pubblicazione su rivista::01l Trial clinico
Low glycaemic diet and metformin therapy. a new approach in male subjects with acne resistant to common treatments / Fabbrocini, G; Izzo, R; Faggiano, A; Del Prete, M; Donnarumma, M; Marasca, C; Marciello, F; Savastano, R; Monfrecola, G; Colao, A. - In: CLINICAL AND EXPERIMENTAL DERMATOLOGY. - ISSN 0307-6938. - 41:1(2016), pp. 38-42. [10.1111/ced.12673]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1675346
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