S UCCESSFUL single lung transplantation (tx) was in troduced in 1983 by the Toronto lung group for patients with pulmonary fibrosis (PF). During the past decade lung tx has been extended to a variety of advanced lung diseases including PF, chronic obstructive pulmonary disease (COPD), antitrypsin deficiency emphysema, cystic fibrosis (CF), primary pulmonary hypertension (PPH), and selected forms of Eisenmenger’s syndrome.‘,’ Expanding indications for lung tx are leading to a greater need for anesthesiologists to be familiar with this procedure and with particular demands of single and bilateral sequential lung tx. It is notable to underline how Conacher3 described lung tx: “A pneumonectomy in a patient who, under normal circumstances, would be adjudged unfit for such an opera tion!” Ventilatory and hemodynamic management and par ticular right ventricular afterload are stressed during lung tx. Pulmonary vasodilators and inotropic agents are man datory during this procedure. Recently, inhaled nitric oxide (iNO) has been used as a pulmonary vasodilator without any effect on systemic hemodynamics. Inhaled NO has been even used in cardiac and thoracic surgery, involving lung tx, especially in postoperative intensive care. Intraoperative iN0 administration for hemodynamic management during lung transplantation was studied in our institution to detect its efficacy during clamping of the pulmonary artery and after reperfusion of the transplanted lung.
Intraoperative inhaled nitric oxide during anesthesia for lung transplant / Rocca, G D; Coccia, C; Pugliese, F; Antonini, M; Pompei, L; Ruberto, F; Venuta, F; Ricci, C; Gasparetto, A. - In: TRANSPLANTATION PROCEEDINGS. - ISSN 0041-1345. - 29:8(1997), pp. 3362-3366. [10.1016/s0041-1345(97)00944-5]
Intraoperative inhaled nitric oxide during anesthesia for lung transplant
Pugliese, F;Ruberto, F;Venuta, F;
1997
Abstract
S UCCESSFUL single lung transplantation (tx) was in troduced in 1983 by the Toronto lung group for patients with pulmonary fibrosis (PF). During the past decade lung tx has been extended to a variety of advanced lung diseases including PF, chronic obstructive pulmonary disease (COPD), antitrypsin deficiency emphysema, cystic fibrosis (CF), primary pulmonary hypertension (PPH), and selected forms of Eisenmenger’s syndrome.‘,’ Expanding indications for lung tx are leading to a greater need for anesthesiologists to be familiar with this procedure and with particular demands of single and bilateral sequential lung tx. It is notable to underline how Conacher3 described lung tx: “A pneumonectomy in a patient who, under normal circumstances, would be adjudged unfit for such an opera tion!” Ventilatory and hemodynamic management and par ticular right ventricular afterload are stressed during lung tx. Pulmonary vasodilators and inotropic agents are man datory during this procedure. Recently, inhaled nitric oxide (iNO) has been used as a pulmonary vasodilator without any effect on systemic hemodynamics. Inhaled NO has been even used in cardiac and thoracic surgery, involving lung tx, especially in postoperative intensive care. Intraoperative iN0 administration for hemodynamic management during lung transplantation was studied in our institution to detect its efficacy during clamping of the pulmonary artery and after reperfusion of the transplanted lung.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.