Lipid metabolism is known to be involved in tumorigenesis and disease progression in many common cancer types, including colon, lung, breast and prostate, through modifications of lipid synthesis, storage and catabolism. Furthermore, lipid alterations may arise as a consequence of cancer treatment and may have a role in treatment resistance. Neuroendocrine neoplasms (NENs) are a heterogeneous group of malignancies with increasing incidence, whose mechanisms of cancer initiation and progression are far from being fully understood. Alterations of lipid metabolism may be common across various cancer types, but data about NENs are scattered and heterogeneous. Herein, we provide an overview of the relevant literature on lipid metabolism and alterations in NENs. The available evidence both in basic and clinical research about lipid metabolism in NENs, including therapeutic effects on lipid homeostasis, are summarized. Additionally, the potential of targeting the lipid profile in NEN therapy is also discussed, and areas for further research are proposed.

Lipid metabolism and homeostasis in patients with neuroendocrine neoplasms: from risk factor to potential therapeutic target / Modica, Roberta; La Salvia, Anna; Liccardi, Alessia; Cannavale, Giuseppe; Minotta, Roberto; Benevento, Elio; Faggiano, Antongiulio; Colao, Annamaria. - In: METABOLITES. - ISSN 2218-1989. - 12:11(2022). [10.3390/metabo12111057]

Lipid metabolism and homeostasis in patients with neuroendocrine neoplasms: from risk factor to potential therapeutic target

Cannavale, Giuseppe;Faggiano, Antongiulio
Penultimo
;
2022

Abstract

Lipid metabolism is known to be involved in tumorigenesis and disease progression in many common cancer types, including colon, lung, breast and prostate, through modifications of lipid synthesis, storage and catabolism. Furthermore, lipid alterations may arise as a consequence of cancer treatment and may have a role in treatment resistance. Neuroendocrine neoplasms (NENs) are a heterogeneous group of malignancies with increasing incidence, whose mechanisms of cancer initiation and progression are far from being fully understood. Alterations of lipid metabolism may be common across various cancer types, but data about NENs are scattered and heterogeneous. Herein, we provide an overview of the relevant literature on lipid metabolism and alterations in NENs. The available evidence both in basic and clinical research about lipid metabolism in NENs, including therapeutic effects on lipid homeostasis, are summarized. Additionally, the potential of targeting the lipid profile in NEN therapy is also discussed, and areas for further research are proposed.
2022
cancer; cancer therapy; cholesterol; lipid metabolism; metabolic syndrome; neuroendocrine neoplasm; neuroendocrine tumor
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
Lipid metabolism and homeostasis in patients with neuroendocrine neoplasms: from risk factor to potential therapeutic target / Modica, Roberta; La Salvia, Anna; Liccardi, Alessia; Cannavale, Giuseppe; Minotta, Roberto; Benevento, Elio; Faggiano, Antongiulio; Colao, Annamaria. - In: METABOLITES. - ISSN 2218-1989. - 12:11(2022). [10.3390/metabo12111057]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1675160
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