Background Pancreaticoduodenectomy represents the major treatment for pancreatic and periampullary neoplasms. Complications related to pancreaticojejunostomy are still the leading cause of morbidity and mortality. A solution proposed by some surgeons is the occlusion of main pancreatic duct by acrylic glue, avoiding pancreaticojejunostomy. Nevertheless, the consequences of this procedure on glucose metabolism are not well-defined. Methods We retrospectively analyzed a cohort of 50 patients who underwent pancreaticoduodenectomy and had metabolic assessments available. The metabolic evaluation included the following: body composition and clinical evaluation, an oral glucose tolerance test, and an hyperinsulinemic euglycemic clamp procedure. Results Twenty-three patients underwent pancreatic duct occlusion and were compared with 27 patients, well-matched controls, who underwent pancreaticojejunostomy. Pancreatic duct occlusion leads to a greater impairment in insulin secretion compared with classic pancreaticojeunostomy. Conclusion Pancreatic duct occlusion is associated with a greater reduction in insulin secretion but does not lead to meaningful differences in the management of patients with diabetes.

Metabolic consequences of the occlusion of the main pancreatic duct with acrylic glue after pancreaticoduodenectomy / Mezza, T.; Clemente, G.; Sorice, G. P.; Conte, C.; De Rose, A. M.; Sun, V. A.; Cefalo, C. M. A.; Pontecorvi, A.; Nuzzo, G.; Giaccari, A.. - In: THE AMERICAN JOURNAL OF SURGERY. - ISSN 0002-9610. - 210:4(2015), pp. 783-789. [10.1016/j.amjsurg.2014.12.052]

Metabolic consequences of the occlusion of the main pancreatic duct with acrylic glue after pancreaticoduodenectomy

Cefalo C. M. A.;
2015

Abstract

Background Pancreaticoduodenectomy represents the major treatment for pancreatic and periampullary neoplasms. Complications related to pancreaticojejunostomy are still the leading cause of morbidity and mortality. A solution proposed by some surgeons is the occlusion of main pancreatic duct by acrylic glue, avoiding pancreaticojejunostomy. Nevertheless, the consequences of this procedure on glucose metabolism are not well-defined. Methods We retrospectively analyzed a cohort of 50 patients who underwent pancreaticoduodenectomy and had metabolic assessments available. The metabolic evaluation included the following: body composition and clinical evaluation, an oral glucose tolerance test, and an hyperinsulinemic euglycemic clamp procedure. Results Twenty-three patients underwent pancreatic duct occlusion and were compared with 27 patients, well-matched controls, who underwent pancreaticojejunostomy. Pancreatic duct occlusion leads to a greater impairment in insulin secretion compared with classic pancreaticojeunostomy. Conclusion Pancreatic duct occlusion is associated with a greater reduction in insulin secretion but does not lead to meaningful differences in the management of patients with diabetes.
2015
insulin secretion; metabolic evaluation; pancreatic duct occlusion; pancreaticoduodenectomy; pancreaticojejunostomy
01 Pubblicazione su rivista::01a Articolo in rivista
Metabolic consequences of the occlusion of the main pancreatic duct with acrylic glue after pancreaticoduodenectomy / Mezza, T.; Clemente, G.; Sorice, G. P.; Conte, C.; De Rose, A. M.; Sun, V. A.; Cefalo, C. M. A.; Pontecorvi, A.; Nuzzo, G.; Giaccari, A.. - In: THE AMERICAN JOURNAL OF SURGERY. - ISSN 0002-9610. - 210:4(2015), pp. 783-789. [10.1016/j.amjsurg.2014.12.052]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1675061
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