The outcome of COVID-19 appears to be influenced by vitamin D status of population. Although epidemiological data indicate that COVID-19 produces more severe symptoms and higher mortality in elderly in comparison to young patients and in men in comparison to women to date sex and age differences in vitamin D status in infected patients have not been evaluated yet. In this study we evaluated the levels of circulating 25(OH)D in patients hospitalized for COVID-19 divided accordingly to their sex and age. We also correlated 25(OH)D levels with patient’s respiratory status (i.e., PaO2/FiO2 ratio) and with sex hormones plasma levels to analyze the potential relationship of these parameters. We found no significant differences in plasma levels of 25(OH)D between pre- and post-menopausal female patients and age matched male patients. Interestingly, the 25(OH)D plasma levels positively correlated to PaO2/FiO2 ratio only in young patients, regardless of their sex. We also found a significantly positive correlation between 17β-estradiol and 25(OH)D in elderly women and between testosterone and 25(OH)D in elderly men, supporting the role of sex hormones in maintaining 25(OH)D levels. In conclusion, we suggest that a synergy between vitamin D and sex hormones could contribute to the age-related outcome of COVID-19.
Synergy between vitamin D and sex hormones in respiratory functionality of patients affected by COVID-19 / Peruzzu, D., Pagano, M.T., Pierdominici, M., Ruggieri, A., Antinori, A., D'Offizi, G., Petrosillo, N., Palmieri, F., Piselli, P., Boumis, E., Notari, S., Nicastri, E., Agrati, C., Ippolito, G., Gagliardi, M.C., Capobianchi, M.R., Ortona, E., Anticoli, S., Bellenghi, M., Bordoni, V., et al.. - In: FRONTIERS IN PHARMACOLOGY. - ISSN 1663-9812. - 12:(2021), pp. 1-5. [10.3389/fphar.2021.683529]
Synergy between vitamin D and sex hormones in respiratory functionality of patients affected by COVID-19
Pagano M. T.Secondo
Writing – Original Draft Preparation
;Pierdominici M.;Notari S.;Nicastri E.;Capobianchi M. R.;Bellenghi M.;Bordoni V.;Cerva C.;Fecchi K.;Gagliardini R.;Di Lorenzo R.;Maffongelli G.;Pontecorvi G.;Vita S.
2021
Abstract
The outcome of COVID-19 appears to be influenced by vitamin D status of population. Although epidemiological data indicate that COVID-19 produces more severe symptoms and higher mortality in elderly in comparison to young patients and in men in comparison to women to date sex and age differences in vitamin D status in infected patients have not been evaluated yet. In this study we evaluated the levels of circulating 25(OH)D in patients hospitalized for COVID-19 divided accordingly to their sex and age. We also correlated 25(OH)D levels with patient’s respiratory status (i.e., PaO2/FiO2 ratio) and with sex hormones plasma levels to analyze the potential relationship of these parameters. We found no significant differences in plasma levels of 25(OH)D between pre- and post-menopausal female patients and age matched male patients. Interestingly, the 25(OH)D plasma levels positively correlated to PaO2/FiO2 ratio only in young patients, regardless of their sex. We also found a significantly positive correlation between 17β-estradiol and 25(OH)D in elderly women and between testosterone and 25(OH)D in elderly men, supporting the role of sex hormones in maintaining 25(OH)D levels. In conclusion, we suggest that a synergy between vitamin D and sex hormones could contribute to the age-related outcome of COVID-19.| File | Dimensione | Formato | |
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