The recognized antibacterial properties of silver nanoparticles (AgNPs) characterize them as attractive nanomaterials for developing new bioactive materials less prone to the development of antibiotic resistance. In this work, we developed new composites based on self-assembling Fmoc-Phe3 peptide hydrogels impregnated with in situ prepared AgNPs. Different methodologies, from traditional to innovative and eco-sustainable, were compared. The obtained composites were characterized from a hydrodynamic, structural, and morphological point of view, using different techniques such as DLS, SEM, and rheological measurements to evaluate how the choice of the reducing agent determines the characteristics of AgNPs and how their presence within the hydrogel affects their structure and properties. Moreover, the antibacterial properties of these composites were tested against S. aureus, a major human pathogen responsible for a wide range of clinical infections. Results demonstrated that the hydrogel composites containing AgNPs (hgel@AgNPs) could represent promising biomaterials for treating S. aureus-related infections.

Preparation of hydrogel composites using a sustainable approach for In situ Silver nanoparticles formation / Chronopoulou, Laura; Binaymotlagh, Roya; Cerra, Sara; Hajareh Haghighi, Farid; Di Domenico, Enea Gino; Sivori, Francesca; Fratoddi, Ilaria; Mignardi, Silvano; Palocci, Cleofe. - In: MATERIALS. - ISSN 1996-1944. - 16:6(2023). [10.3390/ma16062134]

Preparation of hydrogel composites using a sustainable approach for In situ Silver nanoparticles formation

Chronopoulou, Laura;Binaymotlagh, Roya;Cerra, Sara;Hajareh Haghighi, Farid;Di Domenico, Enea Gino;Sivori, Francesca;Fratoddi, Ilaria;Mignardi, Silvano;Palocci, Cleofe
2023

Abstract

The recognized antibacterial properties of silver nanoparticles (AgNPs) characterize them as attractive nanomaterials for developing new bioactive materials less prone to the development of antibiotic resistance. In this work, we developed new composites based on self-assembling Fmoc-Phe3 peptide hydrogels impregnated with in situ prepared AgNPs. Different methodologies, from traditional to innovative and eco-sustainable, were compared. The obtained composites were characterized from a hydrodynamic, structural, and morphological point of view, using different techniques such as DLS, SEM, and rheological measurements to evaluate how the choice of the reducing agent determines the characteristics of AgNPs and how their presence within the hydrogel affects their structure and properties. Moreover, the antibacterial properties of these composites were tested against S. aureus, a major human pathogen responsible for a wide range of clinical infections. Results demonstrated that the hydrogel composites containing AgNPs (hgel@AgNPs) could represent promising biomaterials for treating S. aureus-related infections.
2023
peptide hydrogel; composite; silver nanoparticles
01 Pubblicazione su rivista::01a Articolo in rivista
Preparation of hydrogel composites using a sustainable approach for In situ Silver nanoparticles formation / Chronopoulou, Laura; Binaymotlagh, Roya; Cerra, Sara; Hajareh Haghighi, Farid; Di Domenico, Enea Gino; Sivori, Francesca; Fratoddi, Ilaria; Mignardi, Silvano; Palocci, Cleofe. - In: MATERIALS. - ISSN 1996-1944. - 16:6(2023). [10.3390/ma16062134]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1673950
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