Liver transplantation for primary sclerosing cholangitis (PSC) can be complicated by recurrence of PSC (rPSC). This may compromise graft survival but the effect on patient survival is less clear. We investigated the effect of post-transplant rPSC on graft and patient survival in a large European cohort. Registry data from the European Liver Transplant Registry regarding all first transplants for PSC between 1980 and 2015 were supplemented with detailed data on rPSC from 48 out of 138 contributing transplant centres, involving 1,549 patients. Bayesian proportional hazards models were used to investigate the impact of rPSC and other covariates on patient and graft survival. Recurrence of PSC was diagnosed in 259 patients (16.7%) after a median follow-up of 5.0 years (quantile 2.5%-97.5%: 0.4-18.5), with a significant negative impact on both graft (HR 6.7; 95% CI 4.9-9.1) and patient survival (HR 2.3; 95% CI 1.5-3.3). Patients with rPSC underwent significantly more re-transplants than those without rPSC (OR 3.6, 95% CI 2.7-4.8). PSC recurrence has a negative impact on both graft and patient survival, independent of transplant-related covariates. Recurrence of PSC leads to higher number of re-transplantations and a 33% decrease in 10-year graft survival.

Recurrence of primary sclerosing cholangitis after liver transplantation - analysing the European Liver Transplant Registry and beyond / Visseren, Thijmen; Erler, Nicole Stephanie; Polak, Wojciech Grzegorz; Adam, René; Karam, Vincent; Vondran, Florian Wolfgang Rudolf; Ericzon, Bo-Goran; Thorburn, Douglas; Ijzermans, Jan Nicolaas Maria; Paul, Andreas; van der Heide, Frans; Taimr, Pavel; Nemec, Petr; Pirenne, Jacques; Romagnoli, Renato; Metselaar, Herold Johnny; Darwish Murad, Sarwa; Melandro, Fabio. - In: TRANSPLANT INTERNATIONAL. - ISSN 1432-2277. - 34:8(2021), pp. 1455-1467. [10.1111/tri.13925]

Recurrence of primary sclerosing cholangitis after liver transplantation - analysing the European Liver Transplant Registry and beyond

Melandro, Fabio
Membro del Collaboration Group
2021

Abstract

Liver transplantation for primary sclerosing cholangitis (PSC) can be complicated by recurrence of PSC (rPSC). This may compromise graft survival but the effect on patient survival is less clear. We investigated the effect of post-transplant rPSC on graft and patient survival in a large European cohort. Registry data from the European Liver Transplant Registry regarding all first transplants for PSC between 1980 and 2015 were supplemented with detailed data on rPSC from 48 out of 138 contributing transplant centres, involving 1,549 patients. Bayesian proportional hazards models were used to investigate the impact of rPSC and other covariates on patient and graft survival. Recurrence of PSC was diagnosed in 259 patients (16.7%) after a median follow-up of 5.0 years (quantile 2.5%-97.5%: 0.4-18.5), with a significant negative impact on both graft (HR 6.7; 95% CI 4.9-9.1) and patient survival (HR 2.3; 95% CI 1.5-3.3). Patients with rPSC underwent significantly more re-transplants than those without rPSC (OR 3.6, 95% CI 2.7-4.8). PSC recurrence has a negative impact on both graft and patient survival, independent of transplant-related covariates. Recurrence of PSC leads to higher number of re-transplantations and a 33% decrease in 10-year graft survival.
2021
bayesian statistics; disease recurrence; liver transplantation; patient and graft survival; primary sclerosing cholangitis
01 Pubblicazione su rivista::01a Articolo in rivista
Recurrence of primary sclerosing cholangitis after liver transplantation - analysing the European Liver Transplant Registry and beyond / Visseren, Thijmen; Erler, Nicole Stephanie; Polak, Wojciech Grzegorz; Adam, René; Karam, Vincent; Vondran, Florian Wolfgang Rudolf; Ericzon, Bo-Goran; Thorburn, Douglas; Ijzermans, Jan Nicolaas Maria; Paul, Andreas; van der Heide, Frans; Taimr, Pavel; Nemec, Petr; Pirenne, Jacques; Romagnoli, Renato; Metselaar, Herold Johnny; Darwish Murad, Sarwa; Melandro, Fabio. - In: TRANSPLANT INTERNATIONAL. - ISSN 1432-2277. - 34:8(2021), pp. 1455-1467. [10.1111/tri.13925]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1673896
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