With the increased use of extended-criteria donors, machine perfusion became a beneficial alternative to cold storage in preservation strategy for donor livers with the intent to expand donor pool. Both normothermic and hypothermic approach achieved good results in terms of mid- and long-term outcome in liver transplantation. Many markers and molecules have been proposed for the assessment of liver, but no definitive criteria for graft viability have been validated in large clinical trials and key parameters during perfusion still require optimization.In this review, we address the current literature of viability criteria during normothermic and hypothermic machine perfusion and discuss about future steps and evolution of these technologies.
Viability Criteria during Liver Ex-Situ Normothermic and Hypothermic Perfusion / Melandro, Fabio; De Carlis, Riccardo; Torri, Francesco; Lauterio, Andrea; De Simone, Paolo; De Carlis, Luciano; Ghinolfi, Davide. - In: MEDICINA. - ISSN 1010-660X. - 58:10(2022). [10.3390/medicina58101434]
Viability Criteria during Liver Ex-Situ Normothermic and Hypothermic Perfusion
Melandro, Fabio
;
2022
Abstract
With the increased use of extended-criteria donors, machine perfusion became a beneficial alternative to cold storage in preservation strategy for donor livers with the intent to expand donor pool. Both normothermic and hypothermic approach achieved good results in terms of mid- and long-term outcome in liver transplantation. Many markers and molecules have been proposed for the assessment of liver, but no definitive criteria for graft viability have been validated in large clinical trials and key parameters during perfusion still require optimization.In this review, we address the current literature of viability criteria during normothermic and hypothermic machine perfusion and discuss about future steps and evolution of these technologies.File | Dimensione | Formato | |
---|---|---|---|
Melandro_Viability-Criteria_2022.pdf
accesso aperto
Tipologia:
Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza:
Creative commons
Dimensione
472.23 kB
Formato
Adobe PDF
|
472.23 kB | Adobe PDF |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.