: Different from normal cells, cancer cells must hyperactivate a variety of integrated responses in order to survive their basal stress or its exacerbation caused by exposure to anti-cancer agents. As cancer cells become particularly dependent on these adaptive responses, namely UPR, DDR autophagy, anti-oxidant and heat shock responses, this turns out to be an Achille's heel, which allows them to be selectively killed while sparing normal unstressed cells. Better knowledge of the cross-talk between these adaptive processes and their impact on the immune system is needed to design more effective anti-cancer therapies, as reviewed in this paper.

Interconnected Adaptive Responses: A Way Out for Cancer Cells to Avoid Cellular Demise / D'Orazi, Gabriella; Cirone, Mara. - In: CANCERS. - ISSN 2072-6694. - 14:11(2022), p. 2780. [10.3390/cancers14112780]

Interconnected Adaptive Responses: A Way Out for Cancer Cells to Avoid Cellular Demise

Cirone, Mara
2022

Abstract

: Different from normal cells, cancer cells must hyperactivate a variety of integrated responses in order to survive their basal stress or its exacerbation caused by exposure to anti-cancer agents. As cancer cells become particularly dependent on these adaptive responses, namely UPR, DDR autophagy, anti-oxidant and heat shock responses, this turns out to be an Achille's heel, which allows them to be selectively killed while sparing normal unstressed cells. Better knowledge of the cross-talk between these adaptive processes and their impact on the immune system is needed to design more effective anti-cancer therapies, as reviewed in this paper.
2022
DDR; ER stress; HSPs; UPR; anti-oxidant response; autophagy; cancer; death resistance
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
Interconnected Adaptive Responses: A Way Out for Cancer Cells to Avoid Cellular Demise / D'Orazi, Gabriella; Cirone, Mara. - In: CANCERS. - ISSN 2072-6694. - 14:11(2022), p. 2780. [10.3390/cancers14112780]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1671658
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