Gangliosides (GGs) are a glycolipid class present on Mesenchymal Stem Cells (MSCs) surfaces with a critical appearance role in stem cell differentiation, even though their mechanistic role in signaling and differentiation remains largely unknown. This review aims to carry out a critical analysis of the predictive role of gangliosides as specific markers of the cellular state of undifferentiated and differentiated MSCs, towards the osteogenic, chondrogenic, neurogenic, and adipogenic lineage. For this reason, we analyzed the role of GGs during multilineage differentiation processes of several types of MSCs such as Umbilical Cord-derived MSCs (UC-MSCs), Bone Marrow-derived MSCs (BM-MSCs), Dental Pulp derived MSCs (DPSCs), and Adipose derived MSCs (ADSCs). Moreover, we examined the possible role of GGs as specific cell surface markers to identify or isolate specific stem cell isotypes and their potential use as additional markers for quality control of cell-based therapies.

Gangliosides and their role in multilineage differentiation of mesenchymal stem cells / Santilli, Francesca; Fabrizi, Jessica; Pulcini, Fanny; Santacroce, Costantino; Sorice, Maurizio; Delle Monache, Simona; Mattei, Vincenzo. - In: BIOMEDICINES. - ISSN 2227-9059. - 10:12(2022). [10.3390/biomedicines10123112]

Gangliosides and their role in multilineage differentiation of mesenchymal stem cells

Francesca Santilli
Primo
;
Jessica Fabrizi
Secondo
;
Maurizio Sorice;Vincenzo Mattei
Ultimo
2022

Abstract

Gangliosides (GGs) are a glycolipid class present on Mesenchymal Stem Cells (MSCs) surfaces with a critical appearance role in stem cell differentiation, even though their mechanistic role in signaling and differentiation remains largely unknown. This review aims to carry out a critical analysis of the predictive role of gangliosides as specific markers of the cellular state of undifferentiated and differentiated MSCs, towards the osteogenic, chondrogenic, neurogenic, and adipogenic lineage. For this reason, we analyzed the role of GGs during multilineage differentiation processes of several types of MSCs such as Umbilical Cord-derived MSCs (UC-MSCs), Bone Marrow-derived MSCs (BM-MSCs), Dental Pulp derived MSCs (DPSCs), and Adipose derived MSCs (ADSCs). Moreover, we examined the possible role of GGs as specific cell surface markers to identify or isolate specific stem cell isotypes and their potential use as additional markers for quality control of cell-based therapies.
2022
adipose derived stem cells; bone marrow derived stem cells; dental pulp derived stem cells; gangliosides; mesenchymal stem cells; umbilical cord derived stem cells
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
Gangliosides and their role in multilineage differentiation of mesenchymal stem cells / Santilli, Francesca; Fabrizi, Jessica; Pulcini, Fanny; Santacroce, Costantino; Sorice, Maurizio; Delle Monache, Simona; Mattei, Vincenzo. - In: BIOMEDICINES. - ISSN 2227-9059. - 10:12(2022). [10.3390/biomedicines10123112]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1670846
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