Purpose: The aim of this study was to evaluate the safety and compliance with the enhanced recovery after surgery (ERAS) protocol in octogenarian patients undergoing colorectal surgery in 12 Italian high-volume centers. Methods: A retrospective analysis was conducted in a consecutive series of patients who underwent elective colorectal surgery between 2016 and 2018. Patients were grouped by age (≥ 80 years vs < 80 years), propensity score matching (PSM) analysis was performed, and the groups were compared regarding clinical outcomes and the mean number of ERAS items applied. Results: Out of 1646 patients identified, 310 were octogenarians. PSM identified 2 cohorts of 125 patients for the comparison of postoperative outcomes and ERAS compliance. The 2 groups were homogeneous regarding the clinical variables and mean number of ERAS items applied (11.3 vs 11.9, p-ns); however, the application of intraoperative items was greater in nonelderly patients (p 0.004). The functional recovery was similar between the two groups, as were the rates of postoperative severe complications and 30-day mortality rate. Elderly patients had more overall complications. Furthermore, the mean hospital stay was higher in the elderly group (p 0.027). Multivariable analyses documented that postoperative stay was inversely correlated with the number of ERAS items applied (p < 0.0001), whereas age ≥ 80 years significantly correlated with the overall complication rate (p 0.0419). Conclusion: The ERAS protocol is safe in octogenarian patients, with similar levels of compliance and surgical outcomes. However, octogenarian patients have a higher rate of overall complications and a longer hospital stay than do younger patients.
Enhanced recovery after surgery (ERAS) program in octogenarian patients: a propensity score matching analysis on the “Lazio Network” database / · on behalf of Lazio Network study group (“Lazio Network” Collaborators: Domenico Spoletini, Michele Grieco · Giampaolo Galiffa · Laura Lorenzon · Giuseppe Marincola · Roberto Persiani · Roberto Santoro · Graziano Pernazza · Antonio Brescia · Emanuele Santoro · Francesco Stipa · Antonio Crucitti · Stefano Mancini · Raffaele Macarone Palmieri · Massimiliano Di Paola · Marco Sacchi · Massimo Carlini; Marcellinaro, Rosa; Palla, Filippo; Marco Giorgetti, Gian; D’Ugo, Domenico; Sollazzi, Liliana; Cristina Mele, Maria; Gasbarrini, Antonio; Brunetti, Francesco; Rinninnella, Emanuele; Cintoni, Marco; Adducci, Enrica; Battista Levi San- dri, Giovanni; Marino, Paola; Mancini, Raffaello; Gasparrini, Marcello; Apponi, Fabrizio; Troisi, Fabiana; Romeo, Gherardo; Pedullà, Giuseppe; Donadio, Raffaele; Russo, Giulia; Firmi, Lorenzo; Mazzari, Andrea; Diamanti, Paolo; Muccichini, Lucilla; Menghetti, Damiano; Belardi, Augusto; Angeloni, Riccardo; Bonasera, Elena; Cappelloni, Danela; Minieri, Luciana; Sagnotta, Andrea; Folliero, Gloria; Solinas, Luigi; Amodio, PIETRO MARIA; Arturi, Alessandro; Ferraris, Corrado; Capuano, Giorgio; Puleo, Eugenia; DE STEFANO, Matteo; Palladino, Marcello; Pietrosanti), Francesca. - In: LANGENBECK'S ARCHIVES OF SURGERY. - ISSN 1435-2451. - (2022). [10.1007/s00423-022-02580-y]
Enhanced recovery after surgery (ERAS) program in octogenarian patients: a propensity score matching analysis on the “Lazio Network” database
Rosa Marcellinaro;Francesco Brunetti;Fabrizio Apponi;Gherardo Romeo;Raffaele Donadio;Damiano Menghetti;Luciana Minieri;Andrea Sagnotta;Pietro Maria Amodio;Matteo De Stefano;
2022
Abstract
Purpose: The aim of this study was to evaluate the safety and compliance with the enhanced recovery after surgery (ERAS) protocol in octogenarian patients undergoing colorectal surgery in 12 Italian high-volume centers. Methods: A retrospective analysis was conducted in a consecutive series of patients who underwent elective colorectal surgery between 2016 and 2018. Patients were grouped by age (≥ 80 years vs < 80 years), propensity score matching (PSM) analysis was performed, and the groups were compared regarding clinical outcomes and the mean number of ERAS items applied. Results: Out of 1646 patients identified, 310 were octogenarians. PSM identified 2 cohorts of 125 patients for the comparison of postoperative outcomes and ERAS compliance. The 2 groups were homogeneous regarding the clinical variables and mean number of ERAS items applied (11.3 vs 11.9, p-ns); however, the application of intraoperative items was greater in nonelderly patients (p 0.004). The functional recovery was similar between the two groups, as were the rates of postoperative severe complications and 30-day mortality rate. Elderly patients had more overall complications. Furthermore, the mean hospital stay was higher in the elderly group (p 0.027). Multivariable analyses documented that postoperative stay was inversely correlated with the number of ERAS items applied (p < 0.0001), whereas age ≥ 80 years significantly correlated with the overall complication rate (p 0.0419). Conclusion: The ERAS protocol is safe in octogenarian patients, with similar levels of compliance and surgical outcomes. However, octogenarian patients have a higher rate of overall complications and a longer hospital stay than do younger patients.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
