Neonatal seizures have been associated with the later development of postneonatal epilepsy, mainly beginning within the first year of life. Mechanisms of epileptogenesis in the immature brain still need to be fully elucidated but a two-hit hypothesis, showing that an early insult heightens later susceptibility to seizure-induced brain damage, has been demonstrated in animal models. We describe 2 cases of preterm babies sustaining recurrent neonatal seizures in the context of a severe perinatal brain damage who presented with symptomatic epilepsy only after the occurrence of an episode of febrile status epilepticus. In the context of preexisting perinatal brain damage, febrile status epilepticus acted as a second hit for developing epilepsy, confirming animal evidence.
Symptomatic neonatal seizures followed by febrile status epilepticus: The two-hit hypothesis for the subsequent development of epilepsy / Spagnoli, C.; Cilio, M. R.; Pavlidis, E.; Pisani, F.. - In: JOURNAL OF CHILD NEUROLOGY. - ISSN 0883-0738. - 30:5(2015), pp. 615-618. [10.1177/0883073814533004]
Symptomatic neonatal seizures followed by febrile status epilepticus: The two-hit hypothesis for the subsequent development of epilepsy
Pisani F.
2015
Abstract
Neonatal seizures have been associated with the later development of postneonatal epilepsy, mainly beginning within the first year of life. Mechanisms of epileptogenesis in the immature brain still need to be fully elucidated but a two-hit hypothesis, showing that an early insult heightens later susceptibility to seizure-induced brain damage, has been demonstrated in animal models. We describe 2 cases of preterm babies sustaining recurrent neonatal seizures in the context of a severe perinatal brain damage who presented with symptomatic epilepsy only after the occurrence of an episode of febrile status epilepticus. In the context of preexisting perinatal brain damage, febrile status epilepticus acted as a second hit for developing epilepsy, confirming animal evidence.File | Dimensione | Formato | |
---|---|---|---|
symptomatic neonatal seizures.pdf
solo gestori archivio
Note: Spagnoli_Symptomatic Neonatal Seizures_2015
Tipologia:
Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza:
Tutti i diritti riservati (All rights reserved)
Dimensione
385.61 kB
Formato
Adobe PDF
|
385.61 kB | Adobe PDF | Contatta l'autore |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.