A straightforward assembly of polysubstituted 1,2-dihydro-3H-pyrrolo[1,2-a]indol-3-ones through a domino palladium-catalyzed reaction of indol-2-ylmethyl acetates with 1,3-dicarbonyl derivatives is described. The key role of the features of the 1,3-dicarbonyls on the reaction outcome has been explored. The employment of 2-methylcyclohexan-1,3-dione as the dicarbonyl source could allow further challenging indole nucleus functionalizations.

Synthesis of Polysubstituted 1,2-Dihydro-3H-pyrrolo[1,2-a]indol-3-ones through Domino Palladium-Catalyzed Reactions of Indol-2-ylmethyl Acetates with 1,3-Dicarbonyl Derivatives / Iazzetti, A.; Arcadi, A.; Dessalvi, S.; Fabrizi, G.; Goggiamani, A.; Marrone, F.; Serraiocco, A.; Sferrazza, A.; Ullah, K.. - In: CATALYSTS. - ISSN 2073-4344. - 12:12(2022), p. 1516. [10.3390/catal12121516]

Synthesis of Polysubstituted 1,2-Dihydro-3H-pyrrolo[1,2-a]indol-3-ones through Domino Palladium-Catalyzed Reactions of Indol-2-ylmethyl Acetates with 1,3-Dicarbonyl Derivatives

Dessalvi S.;Fabrizi G.;Goggiamani A.
;
Marrone F.;Serraiocco A.;Sferrazza A.
;
Ullah K.
2022

Abstract

A straightforward assembly of polysubstituted 1,2-dihydro-3H-pyrrolo[1,2-a]indol-3-ones through a domino palladium-catalyzed reaction of indol-2-ylmethyl acetates with 1,3-dicarbonyl derivatives is described. The key role of the features of the 1,3-dicarbonyls on the reaction outcome has been explored. The employment of 2-methylcyclohexan-1,3-dione as the dicarbonyl source could allow further challenging indole nucleus functionalizations.
2022
1,2-dihydro-3h-pyrrolo[1,2-a]indol-3-ones; indolylmethides; palladium catalysis; domino reactions
01 Pubblicazione su rivista::01a Articolo in rivista
Synthesis of Polysubstituted 1,2-Dihydro-3H-pyrrolo[1,2-a]indol-3-ones through Domino Palladium-Catalyzed Reactions of Indol-2-ylmethyl Acetates with 1,3-Dicarbonyl Derivatives / Iazzetti, A.; Arcadi, A.; Dessalvi, S.; Fabrizi, G.; Goggiamani, A.; Marrone, F.; Serraiocco, A.; Sferrazza, A.; Ullah, K.. - In: CATALYSTS. - ISSN 2073-4344. - 12:12(2022), p. 1516. [10.3390/catal12121516]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1670190
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