Transcranial magnetic stimulation (TMS) methods such as cortico-cortical paired associative stimulation (ccPAS) can increase the strength of functional connectivity between ventral premotor cortex (PMv) and primary motor cortex (M1) via spike timing-dependent plasticity (STDP), leading to enhanced motor functions in young adults. However, whether this STDP-inducing protocol is effective in the aging brain remains unclear. In two groups of young and elderly healthy adults, we evaluated manual dexterity with the 9-hole peg task before and after ccPAS of the left PMv- M1 circuit. We observed that ccPAS enhanced dexterity in young adults, and this effect was anticipated by a progressive increase in motor-evoked potentials (MEPs) during ccPAS administration. No similar effects were observed in elderly individuals or in a control task. Across age groups, we observed that the magnitude of MEP changes predicted larger behavioral improvements. These findings demonstrate that left PMv-to-M1 ccPAS induces functionally specific improvements in young adults’ manual dexterity and an increase in corticomotor excitability, but altered plasticity prevents the effectiveness of ccPAS in the elderly.

Transcranial cortico-cortical paired associative stimulation (ccPAS) over ventral premotor-motor pathways enhances action performance and corticomotor excitability in young adults more than in elderly adults / Turrini, Sonia; Bevacqua, Naomi; Cataneo, Antonio; Chiappini, Emilio; Fiori, Francesca; Candidi, Matteo; Avenanti, Alessio. - In: FRONTIERS IN AGING NEUROSCIENCE. - ISSN 1663-4365. - 15:(2023). [10.3389/fnagi.2023.1119508]

Transcranial cortico-cortical paired associative stimulation (ccPAS) over ventral premotor-motor pathways enhances action performance and corticomotor excitability in young adults more than in elderly adults

Bevacqua, Naomi
Secondo
;
Candidi, Matteo
Penultimo
;
Avenanti, Alessio
Ultimo
2023

Abstract

Transcranial magnetic stimulation (TMS) methods such as cortico-cortical paired associative stimulation (ccPAS) can increase the strength of functional connectivity between ventral premotor cortex (PMv) and primary motor cortex (M1) via spike timing-dependent plasticity (STDP), leading to enhanced motor functions in young adults. However, whether this STDP-inducing protocol is effective in the aging brain remains unclear. In two groups of young and elderly healthy adults, we evaluated manual dexterity with the 9-hole peg task before and after ccPAS of the left PMv- M1 circuit. We observed that ccPAS enhanced dexterity in young adults, and this effect was anticipated by a progressive increase in motor-evoked potentials (MEPs) during ccPAS administration. No similar effects were observed in elderly individuals or in a control task. Across age groups, we observed that the magnitude of MEP changes predicted larger behavioral improvements. These findings demonstrate that left PMv-to-M1 ccPAS induces functionally specific improvements in young adults’ manual dexterity and an increase in corticomotor excitability, but altered plasticity prevents the effectiveness of ccPAS in the elderly.
2023
TMS, ccPAS, Hebbian plasticity, manual dexterity, aging, motor system
01 Pubblicazione su rivista::01a Articolo in rivista
Transcranial cortico-cortical paired associative stimulation (ccPAS) over ventral premotor-motor pathways enhances action performance and corticomotor excitability in young adults more than in elderly adults / Turrini, Sonia; Bevacqua, Naomi; Cataneo, Antonio; Chiappini, Emilio; Fiori, Francesca; Candidi, Matteo; Avenanti, Alessio. - In: FRONTIERS IN AGING NEUROSCIENCE. - ISSN 1663-4365. - 15:(2023). [10.3389/fnagi.2023.1119508]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1670029
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