We analyzed clinical and instrumental data of 403 consecutive newborns with gestational age from 24 to 32 weeks, admitted to the University-Hospital of Parma between January 2000 and December 2007, to evaluate the possible relationship between neonatal mortality and occurrence of neonatal seizures in very preterm newborns. Seventy-four subjects died during hospital stay. Seizures were present in 35 neonates, in whom the mortality rate was 37.1%. Multivariate analysis revealed that birth-weight <1000 g (odds ratio: 4.48; 95% confidence interval: 1.47-13.68; P <.01), cardiopulmonary resuscitation (odds ratio: 5.35; 95% confidence interval: 1.19-23.98; P =.02), and moderately and severely abnormal cerebral ultrasound scan findings (odds ratio: 2.48; 95% confidence interval: 1.02-6.05; P <.04; odds ratio: 9.56; 95% confidence interval: 3.45-26.51; P <.01, respectively) were related to the in-hospital mortality but not the presence of neonatal seizures. Our study suggests that neonatal seizures alone are not an independent risk factor for early death in very preterm newborns. © The Author(s) 2012.

Mortality risk after neonatal seizures in very preterm newborns / Pisani, F.; Copioli, C.; Turco, E. C.; Sisti, L.; Cossu, G.; Seri, S.. - In: JOURNAL OF CHILD NEUROLOGY. - ISSN 0883-0738. - 27:10(2012), pp. 1264-1269. [10.1177/0883073811435244]

Mortality risk after neonatal seizures in very preterm newborns

Pisani F.;
2012

Abstract

We analyzed clinical and instrumental data of 403 consecutive newborns with gestational age from 24 to 32 weeks, admitted to the University-Hospital of Parma between January 2000 and December 2007, to evaluate the possible relationship between neonatal mortality and occurrence of neonatal seizures in very preterm newborns. Seventy-four subjects died during hospital stay. Seizures were present in 35 neonates, in whom the mortality rate was 37.1%. Multivariate analysis revealed that birth-weight <1000 g (odds ratio: 4.48; 95% confidence interval: 1.47-13.68; P <.01), cardiopulmonary resuscitation (odds ratio: 5.35; 95% confidence interval: 1.19-23.98; P =.02), and moderately and severely abnormal cerebral ultrasound scan findings (odds ratio: 2.48; 95% confidence interval: 1.02-6.05; P <.04; odds ratio: 9.56; 95% confidence interval: 3.45-26.51; P <.01, respectively) were related to the in-hospital mortality but not the presence of neonatal seizures. Our study suggests that neonatal seizures alone are not an independent risk factor for early death in very preterm newborns. © The Author(s) 2012.
2012
birth weight; mortality; neonatal seizures; newborns; ultrasound; very preterm newborns
01 Pubblicazione su rivista::01a Articolo in rivista
Mortality risk after neonatal seizures in very preterm newborns / Pisani, F.; Copioli, C.; Turco, E. C.; Sisti, L.; Cossu, G.; Seri, S.. - In: JOURNAL OF CHILD NEUROLOGY. - ISSN 0883-0738. - 27:10(2012), pp. 1264-1269. [10.1177/0883073811435244]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1669850
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