Background The wellbeing of oral lichen planus patients (OLPs) may be strongly influenced by a poor quality of sleep (QoS) and psychological impairment. The aims were to analyze the prevalence of sleep disturbance, anxiety, and depression in OLPs and to validate the Pittsburgh Sleep Quality Index (PSQI) in OLPs. Methods Three hundred keratotic OLPs (K-OLPs), 300 with predominant non-keratotic OLP (nK-OLPs), and 300 controls were recruited in 15 Italian universities. The PSQI, Epworth Sleepiness Scale (ESS), Hamilton Rating Scales for Depression and Anxiety (HAM-D and HAM-A), Numeric Rating Scale (NRS), and Total Pain Rating Index (T-PRI) were administered. Results Oral lichen planus patients had statistically higher scores than the controls in the majority of the PSQI sub-items (p-values < 0.001**). Moreover, OLPs had higher scores in the HAM-D, HAM-A, NRS, and T-PRI (p-values < 0.001**). No differences in the PSQI sub-items' scores were found between the K-OLPs and nK-OLPs, although nK-OLPs suffered from higher levels of anxiety, depression, and pain (p-values: HAM-A, 0.007**, HAM-D, 0.009**, NRS, <0.001**, T-PRI, <0.001**). The female gender, anxiety, depression (p-value: 0.007**, 0.001**, 0.020*) and the intensity of pain, anxiety, and depression (p-value: 0.006**, <0.001**, 0.014*) were independent predictors of poor sleep (PSQI > 5) in K-OLPs and nK-OLPs, respectively. The PSQI's validation demonstrated good internal consistency and reliability of both the total and subscale of the PSQI. Conclusions The OLPs reported an overall impaired QoS, which seemed to be an independent parameter according to the regression analysis. Hence, clinicians should assess QoS in OLPs and treat sleep disturbances in order to improve OLPs management.

Assessment of sleep disturbance in oral lichen planus and validation of PSQI: A case-control multicenter study from the SIPMO (Italian Society of Oral Pathology and Medicine) / Adamo, Daniela; Calabria, Elena; Coppola, Noemi; Lo Muzio, Lorenzo; Giuliani, Michele; Azzi, Lorenzo; Maurino, Vittorio; Colella, Giuseppe; Rauso, Raffaele; Montebugnoli, Lucio; Gissi, Davide Bartolomeo; Gabriele, Mario; Nisi, Marco; Sardella, Andrea; Lodi, Giovanni; Varoni, Elena Maria; Giudice, Amerigo; Antonelli, Alessandro; Cabras, Marco; Gambino, Alessio; Vescovi, Paolo; Majorana, Alessandra; Bardellini, Elena; Campisi, Giuseppina; Panzarella, Vera; Spadari, Francesco; Marino, Sonia; Pentenero, Monica; Sutera, Samuele; Biasotto, Matteo; Gobbo, Margherita; Guarda Nardini, Luca; Romeo, Umberto; Tenore, Gianluca; Serpico, Rosario; Lucchese, Alberta; Lajolo, Carlo; Rupe, Cosimo; Aria, Massimo; Gnasso, Agostino; Mignogna, Michele Davide. - In: JOURNAL OF ORAL PATHOLOGY & MEDICINE. - ISSN 0904-2512. - 51:2(2022), pp. 194-205. [10.1111/jop.13255]

Assessment of sleep disturbance in oral lichen planus and validation of PSQI: A case-control multicenter study from the SIPMO (Italian Society of Oral Pathology and Medicine)

Romeo, Umberto;Tenore, Gianluca;
2022

Abstract

Background The wellbeing of oral lichen planus patients (OLPs) may be strongly influenced by a poor quality of sleep (QoS) and psychological impairment. The aims were to analyze the prevalence of sleep disturbance, anxiety, and depression in OLPs and to validate the Pittsburgh Sleep Quality Index (PSQI) in OLPs. Methods Three hundred keratotic OLPs (K-OLPs), 300 with predominant non-keratotic OLP (nK-OLPs), and 300 controls were recruited in 15 Italian universities. The PSQI, Epworth Sleepiness Scale (ESS), Hamilton Rating Scales for Depression and Anxiety (HAM-D and HAM-A), Numeric Rating Scale (NRS), and Total Pain Rating Index (T-PRI) were administered. Results Oral lichen planus patients had statistically higher scores than the controls in the majority of the PSQI sub-items (p-values < 0.001**). Moreover, OLPs had higher scores in the HAM-D, HAM-A, NRS, and T-PRI (p-values < 0.001**). No differences in the PSQI sub-items' scores were found between the K-OLPs and nK-OLPs, although nK-OLPs suffered from higher levels of anxiety, depression, and pain (p-values: HAM-A, 0.007**, HAM-D, 0.009**, NRS, <0.001**, T-PRI, <0.001**). The female gender, anxiety, depression (p-value: 0.007**, 0.001**, 0.020*) and the intensity of pain, anxiety, and depression (p-value: 0.006**, <0.001**, 0.014*) were independent predictors of poor sleep (PSQI > 5) in K-OLPs and nK-OLPs, respectively. The PSQI's validation demonstrated good internal consistency and reliability of both the total and subscale of the PSQI. Conclusions The OLPs reported an overall impaired QoS, which seemed to be an independent parameter according to the regression analysis. Hence, clinicians should assess QoS in OLPs and treat sleep disturbances in order to improve OLPs management.
2022
anxiety; insomnia; mood disturbance; oral lichen planus; sleep disturbance
01 Pubblicazione su rivista::01a Articolo in rivista
Assessment of sleep disturbance in oral lichen planus and validation of PSQI: A case-control multicenter study from the SIPMO (Italian Society of Oral Pathology and Medicine) / Adamo, Daniela; Calabria, Elena; Coppola, Noemi; Lo Muzio, Lorenzo; Giuliani, Michele; Azzi, Lorenzo; Maurino, Vittorio; Colella, Giuseppe; Rauso, Raffaele; Montebugnoli, Lucio; Gissi, Davide Bartolomeo; Gabriele, Mario; Nisi, Marco; Sardella, Andrea; Lodi, Giovanni; Varoni, Elena Maria; Giudice, Amerigo; Antonelli, Alessandro; Cabras, Marco; Gambino, Alessio; Vescovi, Paolo; Majorana, Alessandra; Bardellini, Elena; Campisi, Giuseppina; Panzarella, Vera; Spadari, Francesco; Marino, Sonia; Pentenero, Monica; Sutera, Samuele; Biasotto, Matteo; Gobbo, Margherita; Guarda Nardini, Luca; Romeo, Umberto; Tenore, Gianluca; Serpico, Rosario; Lucchese, Alberta; Lajolo, Carlo; Rupe, Cosimo; Aria, Massimo; Gnasso, Agostino; Mignogna, Michele Davide. - In: JOURNAL OF ORAL PATHOLOGY & MEDICINE. - ISSN 0904-2512. - 51:2(2022), pp. 194-205. [10.1111/jop.13255]
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