Objective: Our aim was to identify early predictors of poor neurodevelopmental outcome and of subsequent epilepsy in very early preterm and late preterm newborns with neonatal seizures. Study design: Fifty-one preterm infants with gestational age (GA) ≤36 weeks were identified among those admitted to the NICU of University Hospital of Parma between January 1999 and December 2003 and prospectively followed-up. They were subdivided in two Groups: early preterm newborns with a GA ≤29 weeks and those with GA between 30 and 36 weeks. Selection criteria included multiple digital-video-EEG confirmed neonatal seizures and a follow-up of at least 30 months. Independent variables considered for analysis included neonatal risk factors, etiology and type of seizures, EEG activity, and cerebral ultrasound scan examinations. Results: Ten infants had a favorable outcome, 17 died, and 23 had an adverse outcome. One infant was lost on follow-up. Apgar score at 1 min (O.R. = 15.457, 95% CI: 2.236-106.850, p = 0.006) and severely abnormal background EEG activity (O.R. = 8.298, 95% CI: 1.316-52.301, p = 0.024) were independent predictors of abnormal outcome. Nine infants presented post-neonatal epilepsy. Severely abnormal Cerebral Ultrasound scans were predictive of epilepsy (O.R. = 13.72, 95% CI: 1.959-96.149, p = 0.008). Conclusions: Neonatal seizures in preterm infants are associated to a high rate of mortality and severe morbidity in survivors but no definitive differences between the two groups of preterm infants were found. Risk-factors for development of subsequent epilepsy are strongly related to the underlying brain damage. © 2007 Elsevier B.V. All rights reserved.

Preterm infants with video-EEG confirmed seizures: Outcome at 30 months of age / Pisani, F.; Barilli, A. L.; Sisti, L.; Bevilacqua, G.; Seri, S.. - In: BRAIN & DEVELOPMENT. - ISSN 0387-7604. - 30:1(2008), pp. 20-30. [10.1016/j.braindev.2007.05.003]

Preterm infants with video-EEG confirmed seizures: Outcome at 30 months of age

Pisani F.;
2008

Abstract

Objective: Our aim was to identify early predictors of poor neurodevelopmental outcome and of subsequent epilepsy in very early preterm and late preterm newborns with neonatal seizures. Study design: Fifty-one preterm infants with gestational age (GA) ≤36 weeks were identified among those admitted to the NICU of University Hospital of Parma between January 1999 and December 2003 and prospectively followed-up. They were subdivided in two Groups: early preterm newborns with a GA ≤29 weeks and those with GA between 30 and 36 weeks. Selection criteria included multiple digital-video-EEG confirmed neonatal seizures and a follow-up of at least 30 months. Independent variables considered for analysis included neonatal risk factors, etiology and type of seizures, EEG activity, and cerebral ultrasound scan examinations. Results: Ten infants had a favorable outcome, 17 died, and 23 had an adverse outcome. One infant was lost on follow-up. Apgar score at 1 min (O.R. = 15.457, 95% CI: 2.236-106.850, p = 0.006) and severely abnormal background EEG activity (O.R. = 8.298, 95% CI: 1.316-52.301, p = 0.024) were independent predictors of abnormal outcome. Nine infants presented post-neonatal epilepsy. Severely abnormal Cerebral Ultrasound scans were predictive of epilepsy (O.R. = 13.72, 95% CI: 1.959-96.149, p = 0.008). Conclusions: Neonatal seizures in preterm infants are associated to a high rate of mortality and severe morbidity in survivors but no definitive differences between the two groups of preterm infants were found. Risk-factors for development of subsequent epilepsy are strongly related to the underlying brain damage. © 2007 Elsevier B.V. All rights reserved.
2008
EEG; Epilepsy; Neonatal seizures; Outcome
01 Pubblicazione su rivista::01a Articolo in rivista
Preterm infants with video-EEG confirmed seizures: Outcome at 30 months of age / Pisani, F.; Barilli, A. L.; Sisti, L.; Bevilacqua, G.; Seri, S.. - In: BRAIN & DEVELOPMENT. - ISSN 0387-7604. - 30:1(2008), pp. 20-30. [10.1016/j.braindev.2007.05.003]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1669822
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