A definite diagnosis of pure small fiber neuropathy (SFN) relies on specific diagnostic testing, such as skin biopsy, quantitative sensory testing (QST), and nociceptive evoked potentials, which require considerable resources that may not be widely available. Accordingly, diagnostic tools with easy implementation in non-specialist centers are warranted to identify patients who require second-level diagnostic tests. In this study, we aimed to test the accuracy of the Small Fiber Neuropathy Symptoms Inventory Questionnaire (SFN-SIQ) in diagnosing pure SFN. We enrolled 86 patients with suspected pure SFN. In these patients, we calculated the diagnostic accuracy of the SFN-SIQ using a combination of clinical examination, QST, and skin biopsy as a reference standard. We found that the SFN-SIQ showed an excellent ability to discriminate between patients with and without pure SFN, with 86% sensitivity and 70% specificity in the diagnosis of pure SFN. Our study providing the diagnostic yield of the SFN-SIQ for pure SFN diagnosis suggests that this questionnaire might be used to screen patients with suspected SFN and identify those requiring second-level diagnostic tests such as QST, skin biopsy, or nociceptive evoked potentials.

The diagnostic accuracy of the small fiber neuropathy symptoms inventory questionnaire (SFN-SIQ) for identifying pure small fiber neuropathy / Galosi, E.; Falco, P.; Di Pietro, G.; Leone, C.; Esposito, N.; De Stefano, G.; Di Stefano, G.; Truini, A.. - In: JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM. - ISSN 1529-8027. - 27:4(2022), pp. 283-290. [10.1111/jns.12513]

The diagnostic accuracy of the small fiber neuropathy symptoms inventory questionnaire (SFN-SIQ) for identifying pure small fiber neuropathy

Galosi E.
Primo
;
Falco P.
Secondo
;
Di Pietro G.;Leone C.;Esposito N.;De Stefano G.;Di Stefano G.
Penultimo
;
Truini A.
Ultimo
2022

Abstract

A definite diagnosis of pure small fiber neuropathy (SFN) relies on specific diagnostic testing, such as skin biopsy, quantitative sensory testing (QST), and nociceptive evoked potentials, which require considerable resources that may not be widely available. Accordingly, diagnostic tools with easy implementation in non-specialist centers are warranted to identify patients who require second-level diagnostic tests. In this study, we aimed to test the accuracy of the Small Fiber Neuropathy Symptoms Inventory Questionnaire (SFN-SIQ) in diagnosing pure SFN. We enrolled 86 patients with suspected pure SFN. In these patients, we calculated the diagnostic accuracy of the SFN-SIQ using a combination of clinical examination, QST, and skin biopsy as a reference standard. We found that the SFN-SIQ showed an excellent ability to discriminate between patients with and without pure SFN, with 86% sensitivity and 70% specificity in the diagnosis of pure SFN. Our study providing the diagnostic yield of the SFN-SIQ for pure SFN diagnosis suggests that this questionnaire might be used to screen patients with suspected SFN and identify those requiring second-level diagnostic tests such as QST, skin biopsy, or nociceptive evoked potentials.
2022
neuropathic pain; skin biopsy; small fiber neuropathy
01 Pubblicazione su rivista::01a Articolo in rivista
The diagnostic accuracy of the small fiber neuropathy symptoms inventory questionnaire (SFN-SIQ) for identifying pure small fiber neuropathy / Galosi, E.; Falco, P.; Di Pietro, G.; Leone, C.; Esposito, N.; De Stefano, G.; Di Stefano, G.; Truini, A.. - In: JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM. - ISSN 1529-8027. - 27:4(2022), pp. 283-290. [10.1111/jns.12513]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1669494
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