Pregnancy-associated breast cancer (PABC) is commonly defined as a breast cancer oc- curring during pregnancy, throughout 1 year postpartum, or during lactation. Despite being a rare circumstance, PABC is one of the most common types of malignancies occurring during pregnancy and lactation, with growing incidence in developed countries, due both to decreasing age at onset of breast cancer and to increasing maternal age. Diagnosis and management of malignancy in the prenatal and postnatal settings are challenging for practitioners, as the structural and functional changes that the breast undergoes may be misleading for both the radiologist and the clinician. Furthermore, safety concerns for the mother and child, as well as psychological aspects in this unique and delicate condition, need to be constantly considered. In this comprehensive review, clinical, diagnostic, and therapeutic aspects of PABC (including surgery, chemotherapy and other systemic treatments, and radiotherapy) are presented and fully discussed, based on medical literature, current international clinical guidelines, and systematic practice.

Pregnancy-associated breast cancer: a diagnostic and therapeutic challenge / Galati, Francesca; Magri, Valentina; Andrea Arias-Cadena, Paula; Moffa, Giuliana; Rizzo, Veronica; Pasculli, Marcella; Botticelli, Andrea; Pediconi, Federica. - In: DIAGNOSTICS. - ISSN 2075-4418. - 13:4(2023). [10.3390/diagnostics13040604]

Pregnancy-associated breast cancer: a diagnostic and therapeutic challenge

Francesca Galati
Co-primo
;
Valentina Magri
Co-primo
;
Giuliana Moffa;Veronica Rizzo;Marcella Pasculli;Andrea Botticelli
Penultimo
;
Federica Pediconi
Ultimo
2023

Abstract

Pregnancy-associated breast cancer (PABC) is commonly defined as a breast cancer oc- curring during pregnancy, throughout 1 year postpartum, or during lactation. Despite being a rare circumstance, PABC is one of the most common types of malignancies occurring during pregnancy and lactation, with growing incidence in developed countries, due both to decreasing age at onset of breast cancer and to increasing maternal age. Diagnosis and management of malignancy in the prenatal and postnatal settings are challenging for practitioners, as the structural and functional changes that the breast undergoes may be misleading for both the radiologist and the clinician. Furthermore, safety concerns for the mother and child, as well as psychological aspects in this unique and delicate condition, need to be constantly considered. In this comprehensive review, clinical, diagnostic, and therapeutic aspects of PABC (including surgery, chemotherapy and other systemic treatments, and radiotherapy) are presented and fully discussed, based on medical literature, current international clinical guidelines, and systematic practice.
2023
PABC; pregnancy; lactation; breast imaging; breast cancer treatment
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
Pregnancy-associated breast cancer: a diagnostic and therapeutic challenge / Galati, Francesca; Magri, Valentina; Andrea Arias-Cadena, Paula; Moffa, Giuliana; Rizzo, Veronica; Pasculli, Marcella; Botticelli, Andrea; Pediconi, Federica. - In: DIAGNOSTICS. - ISSN 2075-4418. - 13:4(2023). [10.3390/diagnostics13040604]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1669080
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