Venous thromboembolism (VTE) is the third most common cause of death worldwide. The incidence of VTE varies according to different countries, ranging from 1–2 per 1000 person-years in Western Countries, while it is lower in Eastern Countries (<1 per 1000 person-years). Many risk factors have been identified in patients developing VTE, but the relative contribution of each risk factor to thrombotic risk, as well as pathogenetic mechanisms, have not been fully described. Herewith, we provide a comprehensive review of the most common risk factors for VTE, including male sex, diabetes, obesity, smoking, Factor V Leiden, Prothrombin G20210A Gene Mutation, Plasminogen Activator Inhibitor-1, oral contraceptives and hormonal replacement, long-haul flight, residual venous thrombosis, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, trauma and fractures, pregnancy, immobilization, antiphospholipid syndrome, surgery and cancer. Regarding the latter, the incidence of VTE seems highest in pancreatic, liver and non-small cells lung cancer (>70 per 1000 person-years) and lowest in breast, melanoma and prostate cancer (<20 per 1000 person-years). In this comprehensive review, we summarized the prevalence of different risk factors for VTE and the potential molecular mechanisms/pathogenetic mediators leading to VTE

A comprehensive review of risk factors for venous thromboembolism. from epidemiology to pathophysiology / Pastori, Daniele; Maria Cormaci, Vito; Marucci, Silvia; Franchino, Giovanni; Del Sole, Francesco; Capozza, Alessandro; Fallarino, Alessia; Corso, Chiara; Valeriani, Emanuele; Menichelli, Danilo; Pignatelli, Pasquale. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1422-0067. - 24:4(2023). [10.3390/ijms24043169]

A comprehensive review of risk factors for venous thromboembolism. from epidemiology to pathophysiology

Daniele Pastori
;
Silvia Marucci;Giovanni Franchino;Alessandro Capozza;Alessia Fallarino;Chiara Corso;Emanuele Valeriani;Danilo Menichelli;Pasquale Pignatelli
2023

Abstract

Venous thromboembolism (VTE) is the third most common cause of death worldwide. The incidence of VTE varies according to different countries, ranging from 1–2 per 1000 person-years in Western Countries, while it is lower in Eastern Countries (<1 per 1000 person-years). Many risk factors have been identified in patients developing VTE, but the relative contribution of each risk factor to thrombotic risk, as well as pathogenetic mechanisms, have not been fully described. Herewith, we provide a comprehensive review of the most common risk factors for VTE, including male sex, diabetes, obesity, smoking, Factor V Leiden, Prothrombin G20210A Gene Mutation, Plasminogen Activator Inhibitor-1, oral contraceptives and hormonal replacement, long-haul flight, residual venous thrombosis, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, trauma and fractures, pregnancy, immobilization, antiphospholipid syndrome, surgery and cancer. Regarding the latter, the incidence of VTE seems highest in pancreatic, liver and non-small cells lung cancer (>70 per 1000 person-years) and lowest in breast, melanoma and prostate cancer (<20 per 1000 person-years). In this comprehensive review, we summarized the prevalence of different risk factors for VTE and the potential molecular mechanisms/pathogenetic mediators leading to VTE
2023
venous thromboembolism; deep vein thrombosis; pulmonary embolism; SARS-CoV-2; cancer; antiphospholipid syndrome; thrombophilia
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
A comprehensive review of risk factors for venous thromboembolism. from epidemiology to pathophysiology / Pastori, Daniele; Maria Cormaci, Vito; Marucci, Silvia; Franchino, Giovanni; Del Sole, Francesco; Capozza, Alessandro; Fallarino, Alessia; Corso, Chiara; Valeriani, Emanuele; Menichelli, Danilo; Pignatelli, Pasquale. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1422-0067. - 24:4(2023). [10.3390/ijms24043169]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1668583
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