Background: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) represents one of the most threatening viral infections in the last decade. Amongst susceptible individuals, infected pregnant women might be predisposed to severe complications. Despite the extensive interest in SARS-CoV-2 research, the clinical course of maternal infection, the vertical transmission and the neonatal outcomes have not been completely understood yet. The aim of our study was to investigate the association between SARS-CoV-2 infection, obstetric outcomes and vertical transmission. Methods: A prospective observational study was performed, enrolling unvaccinated pregnant patients positive for SARS-CoV-2 (cases) and matched with uninfected pregnant women (controls). Maternal and neonatal nasopharyngeal swabs, maternal and cord blood, amniotic fluid and placenta tissue samples were collected; blood samples were tested for anti-S and anti-N antibodies, and histologic examination of placental tissues was performed. Results: The cases showed a significant association with the development of some obstetric complications, such as intrauterine growth restriction and pregnancy-associated hypothyroidism and diabetes, as compared to controls; their newborns were more likely to have a low birth weight and an arterial umbilical pH less than 7. The viral genome was detected in maternal and cord blood and placental samples in six cases. Conclusions: Pregnant women positive for SARS-CoV-2 infection are more likely to develop severe obstetric outcomes; their newborns could have a low birth weight and arterial pH. Vertical transmission seems a rare event, and further investigation is strongly needed.

SARS-CoV-2 infection in pregnancy. Clues and proof of adverse outcomes / Sessa, Rosa; Filardo, Simone; Masciullo, Luisa; DI PIETRO, Marisa; Angeloni, Antonio; Brandolino, Gabriella; Brunelli, Roberto; Dalisa, Rossella; Viscardi, MARIA FEDERICA; Anastasi, Emanuela; Porpora, Maria Grazia. - In: INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH. - ISSN 1660-4601. - 20:3(2023), pp. 1-15. [10.3390/ijerph20032616]

SARS-CoV-2 infection in pregnancy. Clues and proof of adverse outcomes

Rosa Sessa;Simone Filardo;Luisa Masciullo;Marisa Di Pietro;Antonio Angeloni;Gabriella Brandolino;Roberto Brunelli;Rossella DAlisa;Maria Federica Viscardi;Emanuela Anastasi;Maria Grazia Porpora
2023

Abstract

Background: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) represents one of the most threatening viral infections in the last decade. Amongst susceptible individuals, infected pregnant women might be predisposed to severe complications. Despite the extensive interest in SARS-CoV-2 research, the clinical course of maternal infection, the vertical transmission and the neonatal outcomes have not been completely understood yet. The aim of our study was to investigate the association between SARS-CoV-2 infection, obstetric outcomes and vertical transmission. Methods: A prospective observational study was performed, enrolling unvaccinated pregnant patients positive for SARS-CoV-2 (cases) and matched with uninfected pregnant women (controls). Maternal and neonatal nasopharyngeal swabs, maternal and cord blood, amniotic fluid and placenta tissue samples were collected; blood samples were tested for anti-S and anti-N antibodies, and histologic examination of placental tissues was performed. Results: The cases showed a significant association with the development of some obstetric complications, such as intrauterine growth restriction and pregnancy-associated hypothyroidism and diabetes, as compared to controls; their newborns were more likely to have a low birth weight and an arterial umbilical pH less than 7. The viral genome was detected in maternal and cord blood and placental samples in six cases. Conclusions: Pregnant women positive for SARS-CoV-2 infection are more likely to develop severe obstetric outcomes; their newborns could have a low birth weight and arterial pH. Vertical transmission seems a rare event, and further investigation is strongly needed.
2023
sars-cov-2; pregnancy outcomes; vertical transmission; neonatal outcomes
01 Pubblicazione su rivista::01a Articolo in rivista
SARS-CoV-2 infection in pregnancy. Clues and proof of adverse outcomes / Sessa, Rosa; Filardo, Simone; Masciullo, Luisa; DI PIETRO, Marisa; Angeloni, Antonio; Brandolino, Gabriella; Brunelli, Roberto; Dalisa, Rossella; Viscardi, MARIA FEDERICA; Anastasi, Emanuela; Porpora, Maria Grazia. - In: INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH. - ISSN 1660-4601. - 20:3(2023), pp. 1-15. [10.3390/ijerph20032616]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1668207
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