The definition of metabolic syndrome (MetS) has undergone several changes over the years due to the difficulty in establishing universal criteria for it. Underlying the disorders related to MetS is almost invariably a pro-inflammatory state related to altered glucose metabolism, which could lead to elevated cardiovascular risk. Indeed, the complications closely related to MetS are cardiovascular diseases (CVDs) and type 2 diabetes (T2D). It has been observed that the predisposition to metabolic syndrome is modulated by complex interactions between human microbiota, genetic factors, and diet. This review provides a summary of the last decade of literature related to three principal aspects of MetS: (i) the syndrome’s definition and classification, pathophysiology, and treatment approaches; (ii) prediction and diagnosis underlying the biomarkers identified by means of advanced methodologies (NMR, LC/GC-MS, and LC, LC-MS); and (iii) the role of foods and food components in prevention and/or treatment of MetS, demonstrating a possible role of specific foods intake in the development of MetS.

New advances in metabolic syndrome, from prevention to treatment. The role of diet and food / Ambroselli, Donatella; Masciulli, Fabrizio; Romano, Enrico; Catanzaro, Giuseppina; Besharat, ZEIN MERSINI; Massari, MARIA CHIARA; Ferretti, Elisabetta; Migliaccio, Silvia; Izzo, Luana; Ritieni, Alberto; Grosso, Michela; Formichi, Caterina; Dotta, Francesco; Frigerio, Francesco; Barbiera, Eleonora; Giusti, Anna Maria; Ingallina, Cinzia; Mannina, Luisa. - In: NUTRIENTS. - ISSN 2072-6643. - 15:3(2023), pp. 1-39. [10.3390/nu15030640]

New advances in metabolic syndrome, from prevention to treatment. The role of diet and food

Donatella Ambroselli;Fabrizio Masciulli;Enrico Romano;Giuseppina Catanzaro;Zein Mersini Besharat;Maria Chiara Massari;Elisabetta Ferretti;Silvia Migliaccio;Caterina Formichi;Francesco Dotta;Francesco Frigerio;Eleonora Barbiera;Anna Maria Giusti
;
Cinzia Ingallina
;
Luisa Mannina
2023

Abstract

The definition of metabolic syndrome (MetS) has undergone several changes over the years due to the difficulty in establishing universal criteria for it. Underlying the disorders related to MetS is almost invariably a pro-inflammatory state related to altered glucose metabolism, which could lead to elevated cardiovascular risk. Indeed, the complications closely related to MetS are cardiovascular diseases (CVDs) and type 2 diabetes (T2D). It has been observed that the predisposition to metabolic syndrome is modulated by complex interactions between human microbiota, genetic factors, and diet. This review provides a summary of the last decade of literature related to three principal aspects of MetS: (i) the syndrome’s definition and classification, pathophysiology, and treatment approaches; (ii) prediction and diagnosis underlying the biomarkers identified by means of advanced methodologies (NMR, LC/GC-MS, and LC, LC-MS); and (iii) the role of foods and food components in prevention and/or treatment of MetS, demonstrating a possible role of specific foods intake in the development of MetS.
2023
metabolic syndrome; food; food components; diet; metabolomics; biomarkers
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
New advances in metabolic syndrome, from prevention to treatment. The role of diet and food / Ambroselli, Donatella; Masciulli, Fabrizio; Romano, Enrico; Catanzaro, Giuseppina; Besharat, ZEIN MERSINI; Massari, MARIA CHIARA; Ferretti, Elisabetta; Migliaccio, Silvia; Izzo, Luana; Ritieni, Alberto; Grosso, Michela; Formichi, Caterina; Dotta, Francesco; Frigerio, Francesco; Barbiera, Eleonora; Giusti, Anna Maria; Ingallina, Cinzia; Mannina, Luisa. - In: NUTRIENTS. - ISSN 2072-6643. - 15:3(2023), pp. 1-39. [10.3390/nu15030640]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1667979
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