Background: The study aimed to describe the epidemiology and outcomes of hospital-acquired bloodstream infections (HABSIs) between COVID-19 and non-COVID-19 critically ill patients. Methods: We used data from the Eurobact II study, a prospective observational multicontinental cohort study on HABSI treated in ICU. For the current analysis, we selected centers that included both COVID-19 and non-COVID-19 critically ill patients. We performed descriptive statistics between COVID-19 and non-COVID-19 in terms of patients' characteristics, source of infection and microorganism distribution. We studied the association between COVID-19 status and mortality using multivariable fragility Cox models. Results: A total of 53 centers from 19 countries over the 5 continents were eligible. Overall, 829 patients (median age 65 years [IQR 55; 74]; male, n = 538 [64.9%]) were treated for a HABSI. Included patients comprised 252 (30.4%) COVID-19 and 577 (69.6%) non-COVID-19 patients. The time interval between hospital admission and HABSI was similar between both groups. Respiratory sources (40.1 vs. 26.0%, p < 0.0001) and primary HABSI (25.4% vs. 17.2%, p = 0.006) were more frequent in COVID-19 patients. COVID-19 patients had more often enterococcal (20.5% vs. 9%) and Acinetobacter spp. (18.8% vs. 13.6%) HABSIs. Bacteremic COVID-19 patients had an increased mortality hazard ratio (HR) versus non-COVID-19 patients (HR 1.91, 95% CI 1.49-2.45). Conclusions: We showed that the epidemiology of HABSI differed between COVID-19 and non-COVID-19 patients. Enterococcal HABSI predominated in COVID-19 patients. COVID-19 patients with HABSI had elevated risk of mortality. Trial registration ClinicalTrials.org number NCT03937245 . Registered 3 May 2019.

Different epidemiology of bloodstream infections in COVID-19 compared to non-COVID-19 critically ill patients: a descriptive analysis of the Eurobact II study / Niccolò, Buetti; Alexis, Tabah; Ambre, Loiodice; Stéphane, Ruckly; Abdullah Tarik, Aslan; Giorgia, Montrucchio; Andrea, Cortegiani; Nese, Saltoglu; Bircan, Kayaaslan; Firdevs, Aksoy; Akova, Murat; Özlem, Akdoğan; Kemal Tolga, Saracoglu; Cem, Erdogan; Marc, Leone; Ricard, Ferrer; José-Artur, Paiva; Yoshiro, Hayashi; Mahesh, Ramanan; Andrew, Conway Morris; François, Barbier; Jean-François, Timsit; Lipman, Jeffrey; Litton, Edward; Palermo, Anna Maria; Yap, Timothy; Eroglu, Ege; Hosokawa, Koji; Yoshida, Hideki; Fujitani, Shigeki; Zand, Farid; Mahmoodpoor, Ata; Mohammad Nasirodin Tabatabaei, Seyed; Elrabi, Omar; A Almekhlafi, Ghaleb; Vidal, Gabriela; Aparicio, Marta; Alonzo, Irene; A Namendys-Silva, Silvio; Hermosillo, Mariana; Alejandro Castillo, Roberto; De Bus, Liesbet; De Waele, Jan; Hollevoet, Isabelle; De Schryver, Nicolas; Serck, Nicolas; Kovacevic, Pedja; Zlojutro, Biljana; Ruppe, Etienne; Montravers, Philippe; Dulac, Thierry; Castanera, Jérémy; Massri, Alexandre; Guesdon, Charlotte; Garcon, Pierre; Duprey, Matthieu; Philippart, François; Tran, Marc; Bruel, Cédric; Kalfon, Pierre; Badre, Gaëtan; Demeret, Sophie; Le Guennec, Loïc; Bassetti, Matteo; Giacobbe, Daniele; Sales, Gabriele; Daroui, Ivan; Lodi, Giovanni; Ippolito, Mariachiara; Bellina, Davide; Di Guardo, Andrea; Rocco, Monica; Fiorelli, Silvia; Mikstacki, Adam; Peichota, Mariusz; Pietraszek-Grzywaczewska, Iwona; Póvoa, Pedro; Krystopchuk, Andriy; Teresa, Ana; Manuel Pereira de Figueiredo, António; Botelho, Isabel; Costa, Vasco; Pedro Cunha, Rui; Gritsan, Alexey; Belskiy, Vladislav; Furman, Mikhail; Martinez, Maria; Casares, Vanessa; Pilar Gracia Arnillas, Maria; Munoz Bermudez, Rosana; Ubeda, Alejandro; Salgado, Maria; Maseda, Emilio; Suarez De La Rica, Alejandro; Angel Blasco-Navalpotro, Miguel; Orejas Gallego, Alberto; Prazak, Josef; L Pagani, J; Abed-Maillard, S; Topeli Iskit, Arzu; Mehtap, Selcuk; Ceyhun, Solakoğlu; Kaya Kalem, Ayşe; Kurt, Ibrahim; Telli, Murat; Ozturk, Barcin; Baykam, Nurcan; Karaali, Ridvan; Koksal, Iftihar; Bilir, Yeliz; Guzeldag, Seda; Ersoz, Gulden; Evik, Guliz; Bayindir, Yasar; Ersoy, Yasemin; Ercole, Ari; Raj, Ashok; Zormpa, Artemis; Tinaslanidis, George; Khade, Reena; Roshdy, Ashraf; Kannan, Santhana; Antrolikar, Supriya; Marsden, Nicholas; Attwood, Ben; Patel, Jamie; Gurjar, Mohan; Dsilva, Carol; Chandran, Jagadish; El Sanousi, Bashir; Saidahmed, Elfayadh; S Hamid, Hytham K. - In: CRITICAL CARE. - ISSN 1466-609X. - 26:1(2022), p. 319. [10.1186/s13054-022-04166-y]

Different epidemiology of bloodstream infections in COVID-19 compared to non-COVID-19 critically ill patients: a descriptive analysis of the Eurobact II study

Monica Rocco;Silvia Fiorelli;
2022

Abstract

Background: The study aimed to describe the epidemiology and outcomes of hospital-acquired bloodstream infections (HABSIs) between COVID-19 and non-COVID-19 critically ill patients. Methods: We used data from the Eurobact II study, a prospective observational multicontinental cohort study on HABSI treated in ICU. For the current analysis, we selected centers that included both COVID-19 and non-COVID-19 critically ill patients. We performed descriptive statistics between COVID-19 and non-COVID-19 in terms of patients' characteristics, source of infection and microorganism distribution. We studied the association between COVID-19 status and mortality using multivariable fragility Cox models. Results: A total of 53 centers from 19 countries over the 5 continents were eligible. Overall, 829 patients (median age 65 years [IQR 55; 74]; male, n = 538 [64.9%]) were treated for a HABSI. Included patients comprised 252 (30.4%) COVID-19 and 577 (69.6%) non-COVID-19 patients. The time interval between hospital admission and HABSI was similar between both groups. Respiratory sources (40.1 vs. 26.0%, p < 0.0001) and primary HABSI (25.4% vs. 17.2%, p = 0.006) were more frequent in COVID-19 patients. COVID-19 patients had more often enterococcal (20.5% vs. 9%) and Acinetobacter spp. (18.8% vs. 13.6%) HABSIs. Bacteremic COVID-19 patients had an increased mortality hazard ratio (HR) versus non-COVID-19 patients (HR 1.91, 95% CI 1.49-2.45). Conclusions: We showed that the epidemiology of HABSI differed between COVID-19 and non-COVID-19 patients. Enterococcal HABSI predominated in COVID-19 patients. COVID-19 patients with HABSI had elevated risk of mortality. Trial registration ClinicalTrials.org number NCT03937245 . Registered 3 May 2019.
2022
Bacteremia; Bloodstream infection; COVID-19; Enterococcus; ICU-acquired
01 Pubblicazione su rivista::01a Articolo in rivista
Different epidemiology of bloodstream infections in COVID-19 compared to non-COVID-19 critically ill patients: a descriptive analysis of the Eurobact II study / Niccolò, Buetti; Alexis, Tabah; Ambre, Loiodice; Stéphane, Ruckly; Abdullah Tarik, Aslan; Giorgia, Montrucchio; Andrea, Cortegiani; Nese, Saltoglu; Bircan, Kayaaslan; Firdevs, Aksoy; Akova, Murat; Özlem, Akdoğan; Kemal Tolga, Saracoglu; Cem, Erdogan; Marc, Leone; Ricard, Ferrer; José-Artur, Paiva; Yoshiro, Hayashi; Mahesh, Ramanan; Andrew, Conway Morris; François, Barbier; Jean-François, Timsit; Lipman, Jeffrey; Litton, Edward; Palermo, Anna Maria; Yap, Timothy; Eroglu, Ege; Hosokawa, Koji; Yoshida, Hideki; Fujitani, Shigeki; Zand, Farid; Mahmoodpoor, Ata; Mohammad Nasirodin Tabatabaei, Seyed; Elrabi, Omar; A Almekhlafi, Ghaleb; Vidal, Gabriela; Aparicio, Marta; Alonzo, Irene; A Namendys-Silva, Silvio; Hermosillo, Mariana; Alejandro Castillo, Roberto; De Bus, Liesbet; De Waele, Jan; Hollevoet, Isabelle; De Schryver, Nicolas; Serck, Nicolas; Kovacevic, Pedja; Zlojutro, Biljana; Ruppe, Etienne; Montravers, Philippe; Dulac, Thierry; Castanera, Jérémy; Massri, Alexandre; Guesdon, Charlotte; Garcon, Pierre; Duprey, Matthieu; Philippart, François; Tran, Marc; Bruel, Cédric; Kalfon, Pierre; Badre, Gaëtan; Demeret, Sophie; Le Guennec, Loïc; Bassetti, Matteo; Giacobbe, Daniele; Sales, Gabriele; Daroui, Ivan; Lodi, Giovanni; Ippolito, Mariachiara; Bellina, Davide; Di Guardo, Andrea; Rocco, Monica; Fiorelli, Silvia; Mikstacki, Adam; Peichota, Mariusz; Pietraszek-Grzywaczewska, Iwona; Póvoa, Pedro; Krystopchuk, Andriy; Teresa, Ana; Manuel Pereira de Figueiredo, António; Botelho, Isabel; Costa, Vasco; Pedro Cunha, Rui; Gritsan, Alexey; Belskiy, Vladislav; Furman, Mikhail; Martinez, Maria; Casares, Vanessa; Pilar Gracia Arnillas, Maria; Munoz Bermudez, Rosana; Ubeda, Alejandro; Salgado, Maria; Maseda, Emilio; Suarez De La Rica, Alejandro; Angel Blasco-Navalpotro, Miguel; Orejas Gallego, Alberto; Prazak, Josef; L Pagani, J; Abed-Maillard, S; Topeli Iskit, Arzu; Mehtap, Selcuk; Ceyhun, Solakoğlu; Kaya Kalem, Ayşe; Kurt, Ibrahim; Telli, Murat; Ozturk, Barcin; Baykam, Nurcan; Karaali, Ridvan; Koksal, Iftihar; Bilir, Yeliz; Guzeldag, Seda; Ersoz, Gulden; Evik, Guliz; Bayindir, Yasar; Ersoy, Yasemin; Ercole, Ari; Raj, Ashok; Zormpa, Artemis; Tinaslanidis, George; Khade, Reena; Roshdy, Ashraf; Kannan, Santhana; Antrolikar, Supriya; Marsden, Nicholas; Attwood, Ben; Patel, Jamie; Gurjar, Mohan; Dsilva, Carol; Chandran, Jagadish; El Sanousi, Bashir; Saidahmed, Elfayadh; S Hamid, Hytham K. - In: CRITICAL CARE. - ISSN 1466-609X. - 26:1(2022), p. 319. [10.1186/s13054-022-04166-y]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1667636
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