: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by a multifactorial etiology. The primary aim of this study was to estimate HCV and HBV infection prevalence in a cohort of SLE and Cutaneous Lupus Erythematosus (CLE). We assessed the frequency of these infections in our cohort and the possible associations with disease clinical/laboratory features and disease activity status. The prevalence of chronic HBV infection was 2.2% in the CLE group, while no HBsAg positive patients were identified in the SLE group. Conversely, the prevalence of anti-HCV positive was 2.2% in the SLE group while no anti-HCV positive patients were identified in the CLE group. We found no significant association between anti-HBc positive status and clinical manifestations or disease activity status in either group of patients. Hemodialysis resulted significantly associated with anti-HBc positivity in SLE. In the present study, we found HBsAg positivity in CLE patients but not in the Systemic form (SLE); conversely, a similar prevalence of anti-HBc antibodies in both groups was observed. A possible protective role exerted by SLE in HBV infection may be hypothesized. A higher frequency of HCV infection in SLE compared to CLE suggests a possible involvement of HCV in some SLE-related clinical and immunological features.

Hepatitis B and C virus infection in patients with Systemic and Cutaneous Lupus Erythematosus / Lo Presti, Alessandra; Ceccarelli, Fulvia; Dorrucci, Maria; Farchi, Francesca; Pirone, Carmelo; Garufi, Cristina; Valdarchi, Catia; Spinelli, Francesca Romana; Alessandri, Cristiano; Chionne, Paola; Madonna, Elisabetta; Pisani, Giulio; Martina, Antonio; Simeoni, Matteo; Bruni, Roberto; Ciccozzi, Massimo; Iaiani, Giancarlo; Ciccaglione, Anna Rita; Spada, Enea; Conti, Fabrizio. - In: NEW MICROBIOLOGICA. - ISSN 1121-7138. - 45:4(2022), pp. 296-303.

Hepatitis B and C virus infection in patients with Systemic and Cutaneous Lupus Erythematosus

Ceccarelli, Fulvia;Pirone, Carmelo;Garufi, Cristina;Spinelli, Francesca Romana;Alessandri, Cristiano;Bruni, Roberto;Ciccozzi, Massimo;Conti, Fabrizio
2022

Abstract

: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by a multifactorial etiology. The primary aim of this study was to estimate HCV and HBV infection prevalence in a cohort of SLE and Cutaneous Lupus Erythematosus (CLE). We assessed the frequency of these infections in our cohort and the possible associations with disease clinical/laboratory features and disease activity status. The prevalence of chronic HBV infection was 2.2% in the CLE group, while no HBsAg positive patients were identified in the SLE group. Conversely, the prevalence of anti-HCV positive was 2.2% in the SLE group while no anti-HCV positive patients were identified in the CLE group. We found no significant association between anti-HBc positive status and clinical manifestations or disease activity status in either group of patients. Hemodialysis resulted significantly associated with anti-HBc positivity in SLE. In the present study, we found HBsAg positivity in CLE patients but not in the Systemic form (SLE); conversely, a similar prevalence of anti-HBc antibodies in both groups was observed. A possible protective role exerted by SLE in HBV infection may be hypothesized. A higher frequency of HCV infection in SLE compared to CLE suggests a possible involvement of HCV in some SLE-related clinical and immunological features.
2022
Cutaneous Lupus; Hepatitis B virus; Hepatitis C virus; Serological and epidemiological evaluation; Systemic lupus erythematosus
01 Pubblicazione su rivista::01a Articolo in rivista
Hepatitis B and C virus infection in patients with Systemic and Cutaneous Lupus Erythematosus / Lo Presti, Alessandra; Ceccarelli, Fulvia; Dorrucci, Maria; Farchi, Francesca; Pirone, Carmelo; Garufi, Cristina; Valdarchi, Catia; Spinelli, Francesca Romana; Alessandri, Cristiano; Chionne, Paola; Madonna, Elisabetta; Pisani, Giulio; Martina, Antonio; Simeoni, Matteo; Bruni, Roberto; Ciccozzi, Massimo; Iaiani, Giancarlo; Ciccaglione, Anna Rita; Spada, Enea; Conti, Fabrizio. - In: NEW MICROBIOLOGICA. - ISSN 1121-7138. - 45:4(2022), pp. 296-303.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1666839
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