Introduction: Neonatal seizures are frequent but underdiagnosed manifestations of acute brain dysfunction and an important contributor to unfavorable outcomes. Etiology and severity of brain injury are the single strongest outcome determinants. Areas covered: The authors will discuss the prognostic role of acute symptomatic seizures versus brain injury and the main neuroprotective and neurorestorative strategies for full-term and preterm infants. Expert opinion: Prolonged acute symptomatic seizures likely contribute to long-term outcomes by independently adding further brain injury to initial insults. Correct timing and dosing of therapeutic interventions, depending on etiology and gestational ages, need careful evaluation. Although promising strategies are under study, the only standard of care is whole-body therapeutic hypothermia in full-term newborns with hypoxic-ischemic encephalopathy

Acute symptomatic neonatal seizures, brain injury, and long-term outcome: The role of neuroprotective strategies / Pisani, F.; Fusco, C.; Nagarajan, L.; Spagnoli, C.. - In: EXPERT REVIEW OF NEUROTHERAPEUTICS. - ISSN 1473-7175. - 21:2(2021), pp. 189-203. [10.1080/14737175.2021.1848547]

Acute symptomatic neonatal seizures, brain injury, and long-term outcome: The role of neuroprotective strategies

Pisani, F.;
2021

Abstract

Introduction: Neonatal seizures are frequent but underdiagnosed manifestations of acute brain dysfunction and an important contributor to unfavorable outcomes. Etiology and severity of brain injury are the single strongest outcome determinants. Areas covered: The authors will discuss the prognostic role of acute symptomatic seizures versus brain injury and the main neuroprotective and neurorestorative strategies for full-term and preterm infants. Expert opinion: Prolonged acute symptomatic seizures likely contribute to long-term outcomes by independently adding further brain injury to initial insults. Correct timing and dosing of therapeutic interventions, depending on etiology and gestational ages, need careful evaluation. Although promising strategies are under study, the only standard of care is whole-body therapeutic hypothermia in full-term newborns with hypoxic-ischemic encephalopathy
2021
Acute symptomatic; antiseizure medications; brain injury
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
Acute symptomatic neonatal seizures, brain injury, and long-term outcome: The role of neuroprotective strategies / Pisani, F.; Fusco, C.; Nagarajan, L.; Spagnoli, C.. - In: EXPERT REVIEW OF NEUROTHERAPEUTICS. - ISSN 1473-7175. - 21:2(2021), pp. 189-203. [10.1080/14737175.2021.1848547]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1665640
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