Objective: Neuronal excitation/inhibition (E/I) imbalance is a potential cause of neuronal network malfunctioning in Alzheimer's disease (AD), contributing to cognitive dysfunction. Here, we used a novel approach combining transcranial magnetic stimulation (TMS) and electroencephalography (EEG) to probe cortical excitability in different brain areas known to be directly involved in AD pathology. Methods: We performed TMS-EEG recordings targeting the left dorsolateral prefrontal cortex (l-DLPFC), the left posterior parietal cortex (l-PPC), and the precuneus (PC) in a large sample of patients with mild-to-moderate AD (n = 65) that were compared with a group of age-matched healthy controls (n = 21). Results: We found that patients with AD are characterized by a regional cortical hyperexcitability in the PC and, to some extent, in the frontal lobe, as measured by TMS-evoked potentials. Notably, cortical excitability assessed over the l-PPC was comparable between the 2 groups. Furthermore, we found that the individual level of PC excitability was associated with the level of cognitive impairment, as measured with Mini-Mental State Examination, and with corticospinal fluid levels of Aβ42 . Interpretation: Our data provide novel evidence that precuneus cortical hyperexcitability is a key feature of synaptic dysfunction in patients with AD. The current results point to the combined approach of TMS and EEG as a novel promising technique to measure hyperexcitability in patients with AD. This index could represent a useful biomarker to stage disease severity and evaluate response to novel therapies. ANN NEUROL 2022.

Regional Precuneus Cortical Hyperexcitability in Alzheimer's Disease Patients / Casula, E. P.; Borghi, I.; Maiella, M.; Pellicciari, M. C.; Bonni, S.; Mencarelli, L.; Assogna, M.; D'Acunto, A.; Di Lorenzo, F.; Spampinato, D. A.; Santarnecchi, E.; Martorana, A.; Koch, G.. - In: ANNALS OF NEUROLOGY. - ISSN 1531-8249. - (2022). [10.1002/ana.26514]

Regional Precuneus Cortical Hyperexcitability in Alzheimer's Disease Patients

Casula E. P.;Borghi I.;Mencarelli L.;Di Lorenzo F.;Spampinato D. A.;Koch G.
2022

Abstract

Objective: Neuronal excitation/inhibition (E/I) imbalance is a potential cause of neuronal network malfunctioning in Alzheimer's disease (AD), contributing to cognitive dysfunction. Here, we used a novel approach combining transcranial magnetic stimulation (TMS) and electroencephalography (EEG) to probe cortical excitability in different brain areas known to be directly involved in AD pathology. Methods: We performed TMS-EEG recordings targeting the left dorsolateral prefrontal cortex (l-DLPFC), the left posterior parietal cortex (l-PPC), and the precuneus (PC) in a large sample of patients with mild-to-moderate AD (n = 65) that were compared with a group of age-matched healthy controls (n = 21). Results: We found that patients with AD are characterized by a regional cortical hyperexcitability in the PC and, to some extent, in the frontal lobe, as measured by TMS-evoked potentials. Notably, cortical excitability assessed over the l-PPC was comparable between the 2 groups. Furthermore, we found that the individual level of PC excitability was associated with the level of cognitive impairment, as measured with Mini-Mental State Examination, and with corticospinal fluid levels of Aβ42 . Interpretation: Our data provide novel evidence that precuneus cortical hyperexcitability is a key feature of synaptic dysfunction in patients with AD. The current results point to the combined approach of TMS and EEG as a novel promising technique to measure hyperexcitability in patients with AD. This index could represent a useful biomarker to stage disease severity and evaluate response to novel therapies. ANN NEUROL 2022.
2022
TMS; Alzheimer's Disease; EEG
01 Pubblicazione su rivista::01a Articolo in rivista
Regional Precuneus Cortical Hyperexcitability in Alzheimer's Disease Patients / Casula, E. P.; Borghi, I.; Maiella, M.; Pellicciari, M. C.; Bonni, S.; Mencarelli, L.; Assogna, M.; D'Acunto, A.; Di Lorenzo, F.; Spampinato, D. A.; Santarnecchi, E.; Martorana, A.; Koch, G.. - In: ANNALS OF NEUROLOGY. - ISSN 1531-8249. - (2022). [10.1002/ana.26514]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1665518
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