Hydrophilic interaction liquid chromatography (HILIC) today is a well-known and largely applied technique to analyse polar compounds such as pharmaceuticals, metabolites, proteins, peptides, amino acids, oligonucleotides, and carbohydrates. Due to the large number of stationary phases employed for HILIC applications, this review aims to help the reader in choosing a proper stationary phase, which often represents the critical point for the success of a separation. A great offer is present for achiral applications in contrast to the chiral phases developed for HILIC enantioseparations. In the last case, up-to-date solutions are presented.

A Compendium of the Principal Stationary Phases Used in Hydrophilic Interaction Chromatography: Where Have We Arrived? / Guarducci, Maria A.; Fochetti, Andrea; Ciogli, Alessia; Mazzoccanti, Giulia. - In: SEPARATIONS. - ISSN 2297-8739. - 10:1(2022), p. 22. [10.3390/separations10010022]

A Compendium of the Principal Stationary Phases Used in Hydrophilic Interaction Chromatography: Where Have We Arrived?

Maria A. Guarducci;Andrea Fochetti;Alessia Ciogli
;
Giulia Mazzoccanti
2022

Abstract

Hydrophilic interaction liquid chromatography (HILIC) today is a well-known and largely applied technique to analyse polar compounds such as pharmaceuticals, metabolites, proteins, peptides, amino acids, oligonucleotides, and carbohydrates. Due to the large number of stationary phases employed for HILIC applications, this review aims to help the reader in choosing a proper stationary phase, which often represents the critical point for the success of a separation. A great offer is present for achiral applications in contrast to the chiral phases developed for HILIC enantioseparations. In the last case, up-to-date solutions are presented.
2022
HILIC; stationary phases; achiral applications; enantioseparations
01 Pubblicazione su rivista::01a Articolo in rivista
A Compendium of the Principal Stationary Phases Used in Hydrophilic Interaction Chromatography: Where Have We Arrived? / Guarducci, Maria A.; Fochetti, Andrea; Ciogli, Alessia; Mazzoccanti, Giulia. - In: SEPARATIONS. - ISSN 2297-8739. - 10:1(2022), p. 22. [10.3390/separations10010022]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1664406
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