OBJECTIVE: The purpose of the study was to compare the long-term safety and efficacy of laparoscopic surgery and laparotomy approaches to early stage endometrial cancer.STUDY DESIGN: This was a prospective long-term extension study of a randomized controlled study that included 84 patients with clinical stage I endometrial cancer (laparoscopic surgery group, 40 women; laparotomy group, 38 women). Safety and efficacy data were evaluated and analyzed by the intention-to-treat principle.RESULTS: After a follow-up period of 78 months (interquartile range, 7; range, 19-84 months) and 79 months (interquartile range, 6; range, 22-84 months) for laparoscopic surgery and laparotomy groups, respectively, no difference in the cumulative recurrence rates (8/40 [20.0%] and 7/38 [18.4%]; P = .860)and deaths (7/40 [17.5%] and 6/38 [15.8%] patients; P = .839) was detected between groups. No significant differences in overall (P = .535) and disease-free (P = .512) survival were observed.CONCLUSION: The laparoscopic surgery approach to early stage endometrial cancer is as safe and effective a procedure as the laparotomy approach.

Laparoscopic surgery vs laparotomy for early stage endometrial cancer: long-term data of a randomized controlled trial / Zullo, Fulvio; Palomba, Stefano; Falbo, Angela; Russo, Tiziana; Mocciaro, Rita; Tartaglia, Eduardo; Tagliaferri, Piersandro; Mastrantonio, Pasquale. - In: AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY. - ISSN 0002-9378. - 200:3(2009). [10.1016/j.ajog.2008.10.056]

Laparoscopic surgery vs laparotomy for early stage endometrial cancer: long-term data of a randomized controlled trial

Palomba, Stefano;
2009

Abstract

OBJECTIVE: The purpose of the study was to compare the long-term safety and efficacy of laparoscopic surgery and laparotomy approaches to early stage endometrial cancer.STUDY DESIGN: This was a prospective long-term extension study of a randomized controlled study that included 84 patients with clinical stage I endometrial cancer (laparoscopic surgery group, 40 women; laparotomy group, 38 women). Safety and efficacy data were evaluated and analyzed by the intention-to-treat principle.RESULTS: After a follow-up period of 78 months (interquartile range, 7; range, 19-84 months) and 79 months (interquartile range, 6; range, 22-84 months) for laparoscopic surgery and laparotomy groups, respectively, no difference in the cumulative recurrence rates (8/40 [20.0%] and 7/38 [18.4%]; P = .860)and deaths (7/40 [17.5%] and 6/38 [15.8%] patients; P = .839) was detected between groups. No significant differences in overall (P = .535) and disease-free (P = .512) survival were observed.CONCLUSION: The laparoscopic surgery approach to early stage endometrial cancer is as safe and effective a procedure as the laparotomy approach.
2009
endometrial cancer; laparoscopy; laparotomy; surgery; uterine cancer
01 Pubblicazione su rivista::01a Articolo in rivista
Laparoscopic surgery vs laparotomy for early stage endometrial cancer: long-term data of a randomized controlled trial / Zullo, Fulvio; Palomba, Stefano; Falbo, Angela; Russo, Tiziana; Mocciaro, Rita; Tartaglia, Eduardo; Tagliaferri, Piersandro; Mastrantonio, Pasquale. - In: AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY. - ISSN 0002-9378. - 200:3(2009). [10.1016/j.ajog.2008.10.056]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1664119
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