Micronutrients are ions and vitamins humbly required by the human body. They play a main role in several physiological mechanisms and their imbalance is strongly associated with potentially-fatal complications. Micronutrient imbalance is associated with many cardiovascular diseases, such as arrythmias, heart failure, and ischemic heart disease. It has been also observed in coronavirus disease 2019 (COVID-19), particularly in most severe patients. The relationship between cardiovascular diseases and COVID-19 is mutual: the latter triggers cardiovascular disease onset and worsening while patients with previous cardiovascular disease may develop a more severe form of COVID-19. In addition to the well-known pathophysiological mechanisms binding COVID-19 and cardiovascular diseases together, increasing importance is being given to the impact of micronutrient alterations, often present during COVID-19 and able to affect the balance responsible for a good functioning of the cardiovascular system. In particular, hypokalemia, hypomagnesemia, hyponatremia, and hypocalcemia are strongly associated with worse outcome, while vitamin A and D deficiency are associated with thromboembolic events in COVID-19. Thus, considering how frequent the cardiovascular involvement is in patients with COVID-19, and how it majorly affects their prognosis, this manuscript provides a comprehensive review on the role of micronutrient imbalance in the interconnection between COVID-19 and cardiovascular diseases.

The mutual relationship among cardiovascular diseases and COVID-19. focus on micronutrients imbalance / Severino, Paolo; D'Amato, Andrea; Prosperi, Silvia; Myftari, Vincenzo; Labbro Francia, Aurora; Önkaya, Merve; Notari, Claudia; Papisca, Ilaria; Canuti, Elena Sofia; Yarden Revivo, Mia; Birtolo, Lucia Ilaria; Celli, Paola; Galardo, Gioacchino; Maestrini, Viviana; D'Ettorre, Gabriella; Mancone, Massimo; Fedele, Francesco. - In: NUTRIENTS. - ISSN 2072-6643. - 14:16(2022). [10.3390/nu14163439]

The mutual relationship among cardiovascular diseases and COVID-19. focus on micronutrients imbalance

Severino, Paolo
Primo
;
D'Amato, Andrea;Prosperi, Silvia;Myftari, Vincenzo;Labbro Francia, Aurora;Notari, Claudia;Papisca, Ilaria;Canuti, Elena Sofia;Birtolo, Lucia Ilaria;Galardo, Gioacchino;Maestrini, Viviana;d'Ettorre, Gabriella;Mancone, Massimo
Penultimo
;
Fedele, Francesco
Ultimo
2022

Abstract

Micronutrients are ions and vitamins humbly required by the human body. They play a main role in several physiological mechanisms and their imbalance is strongly associated with potentially-fatal complications. Micronutrient imbalance is associated with many cardiovascular diseases, such as arrythmias, heart failure, and ischemic heart disease. It has been also observed in coronavirus disease 2019 (COVID-19), particularly in most severe patients. The relationship between cardiovascular diseases and COVID-19 is mutual: the latter triggers cardiovascular disease onset and worsening while patients with previous cardiovascular disease may develop a more severe form of COVID-19. In addition to the well-known pathophysiological mechanisms binding COVID-19 and cardiovascular diseases together, increasing importance is being given to the impact of micronutrient alterations, often present during COVID-19 and able to affect the balance responsible for a good functioning of the cardiovascular system. In particular, hypokalemia, hypomagnesemia, hyponatremia, and hypocalcemia are strongly associated with worse outcome, while vitamin A and D deficiency are associated with thromboembolic events in COVID-19. Thus, considering how frequent the cardiovascular involvement is in patients with COVID-19, and how it majorly affects their prognosis, this manuscript provides a comprehensive review on the role of micronutrient imbalance in the interconnection between COVID-19 and cardiovascular diseases.
2022
COVID-19; cardiovascular diseases; ions; micronutrients; nutrition; vitamins
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
The mutual relationship among cardiovascular diseases and COVID-19. focus on micronutrients imbalance / Severino, Paolo; D'Amato, Andrea; Prosperi, Silvia; Myftari, Vincenzo; Labbro Francia, Aurora; Önkaya, Merve; Notari, Claudia; Papisca, Ilaria; Canuti, Elena Sofia; Yarden Revivo, Mia; Birtolo, Lucia Ilaria; Celli, Paola; Galardo, Gioacchino; Maestrini, Viviana; D'Ettorre, Gabriella; Mancone, Massimo; Fedele, Francesco. - In: NUTRIENTS. - ISSN 2072-6643. - 14:16(2022). [10.3390/nu14163439]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1663559
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