Background: Approximately 85-90% of congenital cytomegalovirus infections (cCMV) are asymptomatic. Few studies have investigated early and long-term neurodevelopmental outcomes in children with asymptomatic cCMV (acCMV), and the data is contradictory. In the present study, we did investigate the effect of cCMV asymptomatic infection on neurological outcomes and in cognitive, language and motor development at 6 months of age. Methods: Fifty-six children with cCMV asymptomatic infection were followed for 6 months, as part of a long-term surveillance program, examining their neurological and developmental outcomes. Neurological examination and Bayley-III Scales were performed. Results: Clinical evaluation revealed that early neurological outcomes were essentially normal, with minor neurological deficits (i.e., tone abnormalities) in a subgroup of patients. Bayley-III scores were substantially in the normal range, with 14% showing a score less than 85 (-1SD) in the Motor Scale. Children's neurological and neurodevelopmental outcomes at 6 months of age did not differ according to the trimester of infection. Conclusions: Some infants with cCMV asymptomatic infection may present minor neurological abnormalities in early stages of life. It seems useful to monitor this population for early and late neurodevelopmental sequelae.

Early neurodevelopmental outcomes in children with asymptomatic congenital CMV infection / Novelli, Maria; Natale, Fabio; Di Norcia, Anna; Boiani, Arianna; Temofonte, Sara; Calandriello, Francesca; Zitarelli, Cristina; Caravale, Barbara. - In: THE ITALIAN JOURNAL OF PEDIATRICS. - ISSN 1824-7288. - 48:1(2022), p. 203. [10.1186/s13052-022-01387-3]

Early neurodevelopmental outcomes in children with asymptomatic congenital CMV infection

Novelli, Maria
Primo
Membro del Collaboration Group
;
Natale, Fabio
Secondo
Membro del Collaboration Group
;
Di Norcia, Anna
Membro del Collaboration Group
;
Boiani, Arianna
Membro del Collaboration Group
;
Calandriello, Francesca
Membro del Collaboration Group
;
Zitarelli, Cristina
Membro del Collaboration Group
;
Caravale, Barbara
Ultimo
Membro del Collaboration Group
2022

Abstract

Background: Approximately 85-90% of congenital cytomegalovirus infections (cCMV) are asymptomatic. Few studies have investigated early and long-term neurodevelopmental outcomes in children with asymptomatic cCMV (acCMV), and the data is contradictory. In the present study, we did investigate the effect of cCMV asymptomatic infection on neurological outcomes and in cognitive, language and motor development at 6 months of age. Methods: Fifty-six children with cCMV asymptomatic infection were followed for 6 months, as part of a long-term surveillance program, examining their neurological and developmental outcomes. Neurological examination and Bayley-III Scales were performed. Results: Clinical evaluation revealed that early neurological outcomes were essentially normal, with minor neurological deficits (i.e., tone abnormalities) in a subgroup of patients. Bayley-III scores were substantially in the normal range, with 14% showing a score less than 85 (-1SD) in the Motor Scale. Children's neurological and neurodevelopmental outcomes at 6 months of age did not differ according to the trimester of infection. Conclusions: Some infants with cCMV asymptomatic infection may present minor neurological abnormalities in early stages of life. It seems useful to monitor this population for early and late neurodevelopmental sequelae.
2022
Bayley-III; Congenital CMV; Neurodevelopmental outcome; Neurological outcome
01 Pubblicazione su rivista::01a Articolo in rivista
Early neurodevelopmental outcomes in children with asymptomatic congenital CMV infection / Novelli, Maria; Natale, Fabio; Di Norcia, Anna; Boiani, Arianna; Temofonte, Sara; Calandriello, Francesca; Zitarelli, Cristina; Caravale, Barbara. - In: THE ITALIAN JOURNAL OF PEDIATRICS. - ISSN 1824-7288. - 48:1(2022), p. 203. [10.1186/s13052-022-01387-3]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1663402
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