This study investigated whether vitamin D is associated with the presence or severity of chronic tic disorders and their psychiatric comorbidities. This cross-sectional study compared serum 25-hydroxyvitamin D [25(OH)D] (ng/ml) levels among three groups: children and adolescents (3-16 years) with CTD (n = 327); first-degree relatives (3-10 years) of individuals with CTD who were assessed for a period of up to 7 years for possible onset of tics and developed tics within this period (n = 31); and first-degree relatives who did not develop tics and were ≥ 10 years old at their last assessment (n = 93). The relationship between 25(OH)D and the presence and severity of tics, as well as comorbid obsessive-compulsive disorder (OCD) and attention-deficit/hyperactivity disorder (ADHD), were analysed controlling for age, sex, season, centre, latitude, family relatedness, and comorbidities. When comparing the CTD cohort to the unaffected cohort, the observed result was contrary to the one expected: a 10 ng/ml increase in 25(OH)D was associated with higher odds of having CTD (OR 2.08, 95% CI 1.27-3.42, p < 0.01). There was no association between 25(OH)D and tic severity. However, a 10 ng/ml increase in 25(OH)D was associated with lower odds of having comorbid ADHD within the CTD cohort (OR 0.55, 95% CI 0.36-0.84, p = 0.01) and was inversely associated with ADHD symptom severity (β = - 2.52, 95% CI - 4.16-0.88, p < 0.01). In conclusion, lower vitamin D levels were not associated with a higher presence or severity of tics but were associated with the presence and severity of comorbid ADHD in children and adolescents with CTD.

Vitamin D levels in children and adolescents with chronic tic disorders: a multicentre study / Bond, Molly; Moll, Natalie; Rosello, Alicia; Bond, Rod; Schnell, Jaana; Burger, Bianka; J Hoekstra, Pieter; Dietrich, Andrea; Schrag, Anette; Kocovska, Eva; Martino, Davide; Mueller, Norbert; Schwarz, Markus; Meier, Ute-Christiane; Collaborative Group: Alan Apter, Emtics; Baglioni, Valentina; Ball, Juliane; Benaroya-Milshtein, Noa; Bodmer, Benjamin; Bognar, Emese; Burger, Bianka; Buse, Judith; Cardona, Francesco Carmelo Giovanni; Correa Vela, Marta; M Debes, Nanette; Dietrich, Andrea; Cristina Ferro, Maria; Fremer, Carolin; Garcia-Delgar, Blanca; Gulisano, Mariangela; Hagen, Annelieke; Hagstrøm, Julie; J Hedderly, Tammy; Heyman, Isobel; J Hoekstra, Pieter; Huyser, Chaim; Madruga-Garrido, Marcos; Marotta, Anna; Martino, Davide; Mir, Pablo; Morer, Astrid; Müller, Norbert; R Müller-Vahl, Kirsten; Münchau, Alexander; Nagy, Peter; Neri, Valeria; Jc Openneer, Thaïra; Pellico, Alessandra; Periañez Vasco, Ángela; J Plessen, Kerstin; Porcelli, Cesare; Redondo, Marina; Rizzo, Renata; Roessner, Veit; Ruhrman, Daphna; Ml Schnell, Jaana; Schrag, Anette; Silvestri, PAOLA ROSARIA; Skov, Liselotte; Steinberg, Tamar; Tagwerker Gloor, Friederike; Tarnok, Zsanett; Tübing, Jennifer; L Turner, Victoria; Walitza, Susanne; Weidinger, Elif. - In: EUROPEAN CHILD & ADOLESCENT PSYCHIATRY. - ISSN 1018-8827. - (2022). [10.1007/s00787-021-01757-y]

Vitamin D levels in children and adolescents with chronic tic disorders: a multicentre study

Davide Martino;Valentina Baglioni;Francesco Cardona;Davide Martino;Valeria Neri;Alessandra Pellico;Renata Rizzo;Paola Rosaria Silvestri;
2022

Abstract

This study investigated whether vitamin D is associated with the presence or severity of chronic tic disorders and their psychiatric comorbidities. This cross-sectional study compared serum 25-hydroxyvitamin D [25(OH)D] (ng/ml) levels among three groups: children and adolescents (3-16 years) with CTD (n = 327); first-degree relatives (3-10 years) of individuals with CTD who were assessed for a period of up to 7 years for possible onset of tics and developed tics within this period (n = 31); and first-degree relatives who did not develop tics and were ≥ 10 years old at their last assessment (n = 93). The relationship between 25(OH)D and the presence and severity of tics, as well as comorbid obsessive-compulsive disorder (OCD) and attention-deficit/hyperactivity disorder (ADHD), were analysed controlling for age, sex, season, centre, latitude, family relatedness, and comorbidities. When comparing the CTD cohort to the unaffected cohort, the observed result was contrary to the one expected: a 10 ng/ml increase in 25(OH)D was associated with higher odds of having CTD (OR 2.08, 95% CI 1.27-3.42, p < 0.01). There was no association between 25(OH)D and tic severity. However, a 10 ng/ml increase in 25(OH)D was associated with lower odds of having comorbid ADHD within the CTD cohort (OR 0.55, 95% CI 0.36-0.84, p = 0.01) and was inversely associated with ADHD symptom severity (β = - 2.52, 95% CI - 4.16-0.88, p < 0.01). In conclusion, lower vitamin D levels were not associated with a higher presence or severity of tics but were associated with the presence and severity of comorbid ADHD in children and adolescents with CTD.
2022
ADHD; OCD; Pediatrics; Tic disorder; Tourette; Vitamin D
01 Pubblicazione su rivista::01a Articolo in rivista
Vitamin D levels in children and adolescents with chronic tic disorders: a multicentre study / Bond, Molly; Moll, Natalie; Rosello, Alicia; Bond, Rod; Schnell, Jaana; Burger, Bianka; J Hoekstra, Pieter; Dietrich, Andrea; Schrag, Anette; Kocovska, Eva; Martino, Davide; Mueller, Norbert; Schwarz, Markus; Meier, Ute-Christiane; Collaborative Group: Alan Apter, Emtics; Baglioni, Valentina; Ball, Juliane; Benaroya-Milshtein, Noa; Bodmer, Benjamin; Bognar, Emese; Burger, Bianka; Buse, Judith; Cardona, Francesco Carmelo Giovanni; Correa Vela, Marta; M Debes, Nanette; Dietrich, Andrea; Cristina Ferro, Maria; Fremer, Carolin; Garcia-Delgar, Blanca; Gulisano, Mariangela; Hagen, Annelieke; Hagstrøm, Julie; J Hedderly, Tammy; Heyman, Isobel; J Hoekstra, Pieter; Huyser, Chaim; Madruga-Garrido, Marcos; Marotta, Anna; Martino, Davide; Mir, Pablo; Morer, Astrid; Müller, Norbert; R Müller-Vahl, Kirsten; Münchau, Alexander; Nagy, Peter; Neri, Valeria; Jc Openneer, Thaïra; Pellico, Alessandra; Periañez Vasco, Ángela; J Plessen, Kerstin; Porcelli, Cesare; Redondo, Marina; Rizzo, Renata; Roessner, Veit; Ruhrman, Daphna; Ml Schnell, Jaana; Schrag, Anette; Silvestri, PAOLA ROSARIA; Skov, Liselotte; Steinberg, Tamar; Tagwerker Gloor, Friederike; Tarnok, Zsanett; Tübing, Jennifer; L Turner, Victoria; Walitza, Susanne; Weidinger, Elif. - In: EUROPEAN CHILD & ADOLESCENT PSYCHIATRY. - ISSN 1018-8827. - (2022). [10.1007/s00787-021-01757-y]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1663020
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