Takotsubo syndrome (TTS) is estimated to account for 1-3% of all patients presenting with suspected ST-segment elevation myocardial infarction. A sudden surge in sympathetic nervous system is considered the cause of TTS. Nonetheless, no specific recommendations have been provided regarding β-blocking therapy. Apart from specific contra-indications (severe LV dysfunction, hypotension, bradycardia and corrected QT interval >500 ms), treatment with a β-blocker seems reasonable until full recovery of LV ejection fraction, though evidence is limited to a few animal studies, case reports or observational studies. In this review, we will reappraise the rationale for β-blocker therapy in TTS and speculate on the pathophysiologic basis for preferring non-selective agents with vasodilating activity over β1-selective drugs.

Indications of beta-adrenoceptor blockers in takotsubo syndrome and theoretical reasons to prefer agents with vasodilating activity / Aimo, Alberto; Pelliccia, Francesco; Panichella, Giorgia; Vergaro, Giuseppe; Barison, Andrea; Passino, Claudio; Emdin, Michele; Camici, Paolo G. - In: INTERNATIONAL JOURNAL OF CARDIOLOGY. - ISSN 0167-5273. - 333:(2021), pp. 45-50. [10.1016/j.ijcard.2021.02.074]

Indications of beta-adrenoceptor blockers in takotsubo syndrome and theoretical reasons to prefer agents with vasodilating activity

Pelliccia, Francesco;
2021

Abstract

Takotsubo syndrome (TTS) is estimated to account for 1-3% of all patients presenting with suspected ST-segment elevation myocardial infarction. A sudden surge in sympathetic nervous system is considered the cause of TTS. Nonetheless, no specific recommendations have been provided regarding β-blocking therapy. Apart from specific contra-indications (severe LV dysfunction, hypotension, bradycardia and corrected QT interval >500 ms), treatment with a β-blocker seems reasonable until full recovery of LV ejection fraction, though evidence is limited to a few animal studies, case reports or observational studies. In this review, we will reappraise the rationale for β-blocker therapy in TTS and speculate on the pathophysiologic basis for preferring non-selective agents with vasodilating activity over β1-selective drugs.
2021
myocardial infarction; sympathetic activation; takotsubo syndrome; β-blockers
01 Pubblicazione su rivista::01a Articolo in rivista
Indications of beta-adrenoceptor blockers in takotsubo syndrome and theoretical reasons to prefer agents with vasodilating activity / Aimo, Alberto; Pelliccia, Francesco; Panichella, Giorgia; Vergaro, Giuseppe; Barison, Andrea; Passino, Claudio; Emdin, Michele; Camici, Paolo G. - In: INTERNATIONAL JOURNAL OF CARDIOLOGY. - ISSN 0167-5273. - 333:(2021), pp. 45-50. [10.1016/j.ijcard.2021.02.074]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1662958
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