T-helper 17 (Th17) cells represent a subpopulation of CD4+ T lymphocytes that play an essential role in defense against pathogens. Th17 cells are distinguished from Th1 and Th2 cells by their ability to produce members of the interleukin-17 (IL-17) family, namely IL-17A and IL-17F. IL-17 in turn induces several target cells to synthesize and release cytokines, chemokines, and metalloproteinases, thereby amplifying the inflammatory cascade. Th17 cells reside predominantly in the lamina propria of the mucosa. Their main physiological function is to maintain the integrity of the mucosal barrier against the aggression of infectious agents. However, in an appropriate inflammatory microenvironment, Th17 cells can transform into immunopathogenic cells, giving rise to inflammatory and autoimmune diseases. This review aims to analyze the complex mechanisms through which the interaction between Th17 and pathogens can be on the one hand favorable to the host by protecting it from infectious agents, and on the other hand harmful, potentially generating autoimmune reactions and tissue damage.

The double game played by Th17 cells in infection: host defense and immunopathology / Paroli, Marino; Caccavale, Rosalba; Fiorillo, Maria Teresa; Spadea, Luca; Gumina, Stefano; Candela, Vittorio; Paroli, Maria Pia. - In: PATHOGENS. - ISSN 2076-0817. - 11:12(2022). [10.3390/pathogens11121547]

The double game played by Th17 cells in infection: host defense and immunopathology

Paroli, Marino
Primo
;
Caccavale, Rosalba
Secondo
;
Fiorillo, Maria Teresa;Spadea, Luca;Gumina, Stefano;Candela, Vittorio
Penultimo
;
Paroli, Maria Pia
Ultimo
2022

Abstract

T-helper 17 (Th17) cells represent a subpopulation of CD4+ T lymphocytes that play an essential role in defense against pathogens. Th17 cells are distinguished from Th1 and Th2 cells by their ability to produce members of the interleukin-17 (IL-17) family, namely IL-17A and IL-17F. IL-17 in turn induces several target cells to synthesize and release cytokines, chemokines, and metalloproteinases, thereby amplifying the inflammatory cascade. Th17 cells reside predominantly in the lamina propria of the mucosa. Their main physiological function is to maintain the integrity of the mucosal barrier against the aggression of infectious agents. However, in an appropriate inflammatory microenvironment, Th17 cells can transform into immunopathogenic cells, giving rise to inflammatory and autoimmune diseases. This review aims to analyze the complex mechanisms through which the interaction between Th17 and pathogens can be on the one hand favorable to the host by protecting it from infectious agents, and on the other hand harmful, potentially generating autoimmune reactions and tissue damage.
2022
Th17; pathogens; immunopathology
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
The double game played by Th17 cells in infection: host defense and immunopathology / Paroli, Marino; Caccavale, Rosalba; Fiorillo, Maria Teresa; Spadea, Luca; Gumina, Stefano; Candela, Vittorio; Paroli, Maria Pia. - In: PATHOGENS. - ISSN 2076-0817. - 11:12(2022). [10.3390/pathogens11121547]
File allegati a questo prodotto
File Dimensione Formato  
Paroli_The Double_2022.pdf

accesso aperto

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Creative commons
Dimensione 1.06 MB
Formato Adobe PDF
1.06 MB Adobe PDF

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1662680
Citazioni
  • ???jsp.display-item.citation.pmc??? 11
  • Scopus 15
  • ???jsp.display-item.citation.isi??? 12
social impact