In adult human brain, neurogenesis seems to persist throughout life and ischemic stroke was proved to stimulate this process. Using magnetic resonance spectroscopy (MRS), a 1.28-ppm peak, putative biomarker of neural progenitor cells (NPCs), was identified both in vitro and in vivo, i.e., in normal rat and healthy human brain. The aim of our study was to identify a 1.28-ppm peak in adult human ischemic brain by using 3.0 T multivoxel MRS.
A transient magnetic resonance spectroscopy peri-ischemic peak: a possible radiological biomarker of post-stroke neurogenesis / De Michele, Manuela; Iacobucci, Marta; Letteri, Federica; Andreoli, Chiara; Lorenzano, Svetlana; Canese, Rossella; Petraglia, Luca; Berto, Irene; Schiavo, Oscar Gaetano; Di Biasi, Claudio; Toni, Danilo. - In: NEUROLOGICAL SCIENCES. - ISSN 1590-3478. - (2022). [10.1007/s10072-022-06479-w]
A transient magnetic resonance spectroscopy peri-ischemic peak: a possible radiological biomarker of post-stroke neurogenesis
De Michele, Manuela;Iacobucci, Marta;Letteri, Federica;Lorenzano, Svetlana;Petraglia, Luca;Berto, Irene;Toni, Danilo
2022
Abstract
In adult human brain, neurogenesis seems to persist throughout life and ischemic stroke was proved to stimulate this process. Using magnetic resonance spectroscopy (MRS), a 1.28-ppm peak, putative biomarker of neural progenitor cells (NPCs), was identified both in vitro and in vivo, i.e., in normal rat and healthy human brain. The aim of our study was to identify a 1.28-ppm peak in adult human ischemic brain by using 3.0 T multivoxel MRS.| File | Dimensione | Formato | |
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