Background: The use of intratympanic (IT) steroids has drastically increased over the past 10-15 years to manage many otological pathologies. Objectives: This study aimed to compare the concentrations of prednisolone and prednisolone sodium succinate (SS) in the plasma and inner ear perilymph of participants who underwent cochlear implantation 24 h after IT injection. Materials and methods: It was a prospective comparative randomized study. Twenty participants received an IT injection of prednisolone SS ∼24 h before the cochlear implantation. The other five participants received an IT saline injection and represented the control group. Perilymph and blood were sampled during the cochlear implantation surgery. Results: Both prednisolone and prednisolone SS were still present in perilymph ∼24 h after the IT administration. Only prednisolone was present in the blood plasma of seven participants (35%). Conclusion: IT injection of prednisolone SS resulted in high perilymph concentrations of prednisolone and prednisolone SS, which could stay in the perilymph for at least 24 h. Using a mini-endoscope during the IT injection may effectively detect barriers infront of the round window membrane, increasing the drug concentration in the inner ear. Significance: IT injection is an effective method for delivering prednisolone to the inner ear.
Evaluation of prednisolone and prednisolone sodium succinate concentrations in human plasma and inner ear perilymph during cochlear implantation 24 h after intratympanic injection / Covelli, Edoardo; Filippi, Chiara; Filipo, Roberto; Palumbo, Giancarlo; Di Giovanni, Carmen; Elfarargy &, Haitham H.; Barbara, Maurizio. - In: ACTA OTO-LARYNGOLOGICA. - ISSN 1651-2251. - 1(2022), pp. 1-6. [10.1080/00016489.2022.2146747]
Evaluation of prednisolone and prednisolone sodium succinate concentrations in human plasma and inner ear perilymph during cochlear implantation 24 h after intratympanic injection
Edoardo Covelli
Primo
;Chiara FilippiSecondo
;Roberto Filipo;Maurizio BarbaraUltimo
2022
Abstract
Background: The use of intratympanic (IT) steroids has drastically increased over the past 10-15 years to manage many otological pathologies. Objectives: This study aimed to compare the concentrations of prednisolone and prednisolone sodium succinate (SS) in the plasma and inner ear perilymph of participants who underwent cochlear implantation 24 h after IT injection. Materials and methods: It was a prospective comparative randomized study. Twenty participants received an IT injection of prednisolone SS ∼24 h before the cochlear implantation. The other five participants received an IT saline injection and represented the control group. Perilymph and blood were sampled during the cochlear implantation surgery. Results: Both prednisolone and prednisolone SS were still present in perilymph ∼24 h after the IT administration. Only prednisolone was present in the blood plasma of seven participants (35%). Conclusion: IT injection of prednisolone SS resulted in high perilymph concentrations of prednisolone and prednisolone SS, which could stay in the perilymph for at least 24 h. Using a mini-endoscope during the IT injection may effectively detect barriers infront of the round window membrane, increasing the drug concentration in the inner ear. Significance: IT injection is an effective method for delivering prednisolone to the inner ear.File | Dimensione | Formato | |
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Covelli_Evaluation of prednisolone_2022.pdf
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