Neurofibromatosis type 1 (NF1), or von Recklinghausen’s disease, is an autosomal dominant condition with an incidence of 1:3000 and a prevalence of 1:4000 to 1:5000. It is caused by mutations in the NF1 tumor suppressor gene, located on chromosome 17 (17q11.2), which encodes neurofibromin, a protein able to down regulate the Ras-Raf/MAPK signaling pathway that activates cell proliferation
Halo-like phenomenon in a patient with neurofibromatosis type 1 and mongolian spot / Miraglia, Emanuele; Giustini, Sandra. - In: ITALIAN JOURNAL OF DERMATOLOGY AND VENEREOLOGY. - ISSN 2784-8450. - 156:6(2021), pp. 726-727. [10.23736/S2784-8671.20.06538-4]
Halo-like phenomenon in a patient with neurofibromatosis type 1 and mongolian spot
Miraglia, Emanuele
;Giustini, Sandra
2021
Abstract
Neurofibromatosis type 1 (NF1), or von Recklinghausen’s disease, is an autosomal dominant condition with an incidence of 1:3000 and a prevalence of 1:4000 to 1:5000. It is caused by mutations in the NF1 tumor suppressor gene, located on chromosome 17 (17q11.2), which encodes neurofibromin, a protein able to down regulate the Ras-Raf/MAPK signaling pathway that activates cell proliferation| File | Dimensione | Formato | |
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