In a male with severe proctitis, monkeypox virus DNA was detected in skin lesions, blood, nasopharynx, and rectum, underlying the generalized viral spreading. Rectal involvement was still found when skin lesions disappeared. At the early-stage, increase of cytotoxic and activated T-cells, while reduction of CD56dimCD57+NK cells compared to recovery time-point was observed.

Longitudinal virological and immunological profile in a case of human monkeypox infection / Zingaropoli, MARIA ANTONELLA; Parente, Alberico; Kertusha, Blerta; Campagna, Roberta; Tieghi, Tiziana; Garattini, Silvia; Marocco, Raffaella; Carraro, Anna; Tortellini, Eeva; Guardiani, Mariasilvia; Dominelli, Federica; Turriziani, Ombretta; Ciardi, Maria Rosa; Mastroianni, Claudio Maria; Del Borgo, Cosmo; Lichtner, Miriam. - In: OPEN FORUM INFECTIOUS DISEASES. - ISSN 2328-8957. - 9:12(2022), pp. 1-5. [10.1093/ofid/ofac569]

Longitudinal virological and immunological profile in a case of human monkeypox infection

Maria Antonella Zingaropoli
;
Alberico Parente;Blerta Kertusha;Roberta Campagna;Tiziana Tieghi;Silvia Garattini;Raffaella Marocco;Anna Carraro;Eeva Tortellini;Mariasilvia Guardiani;Federica Dominelli;Ombretta Turriziani;Maria Rosa Ciardi;Claudio Maria Mastroianni;Miriam Lichtner
2022

Abstract

In a male with severe proctitis, monkeypox virus DNA was detected in skin lesions, blood, nasopharynx, and rectum, underlying the generalized viral spreading. Rectal involvement was still found when skin lesions disappeared. At the early-stage, increase of cytotoxic and activated T-cells, while reduction of CD56dimCD57+NK cells compared to recovery time-point was observed.
2022
mpx; mpxv; flow cytometry; immunophenotyping; nk cells; immune activation; proctitis; cytotoxic cells
01 Pubblicazione su rivista::01a Articolo in rivista
Longitudinal virological and immunological profile in a case of human monkeypox infection / Zingaropoli, MARIA ANTONELLA; Parente, Alberico; Kertusha, Blerta; Campagna, Roberta; Tieghi, Tiziana; Garattini, Silvia; Marocco, Raffaella; Carraro, Anna; Tortellini, Eeva; Guardiani, Mariasilvia; Dominelli, Federica; Turriziani, Ombretta; Ciardi, Maria Rosa; Mastroianni, Claudio Maria; Del Borgo, Cosmo; Lichtner, Miriam. - In: OPEN FORUM INFECTIOUS DISEASES. - ISSN 2328-8957. - 9:12(2022), pp. 1-5. [10.1093/ofid/ofac569]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1661168
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