The efficacy of the treatment of bacterial infection is seriously reduced because of antibiotic resistance; thus, therapeutic solutions against drug-resistant microbes are necessary. Nanoparticle-based solutions are particularly promising for meeting this challenge because they can offer intrinsic antimicrobial activity and sustained drug release at the target site. Herein, we present a newly developed nanovesicle system of the quatsome family, composed of l-prolinol-derived surfactants and cholesterol, which has noticeable antibacterial activity even on Gram-negative strains, demonstrating great potential for the treatment of bacterial infections. We optimized the vesicle stability and antibacterial activity by tuning the surfactant chain length and headgroup charge (cationic or zwitterionic) and show that these quatsomes can furthermore serve as nanocarriers of pharmaceutical actives, demonstrated here by the encapsulation of (+)-usnic acid, a natural substance with many pharmacological properties.

Quatsomes Formulated with l -Prolinol-Derived Surfactants as Antibacterial Nanocarriers of (+)-Usnic Acid with Antioxidant Activity / Battista, S.; Kober, M.; Bellio, P.; Celenza, G.; Galantini, L.; Vargas-Nadal, G.; Fagnani, L.; Veciana, J.; Ventosa, N.; Giansanti, L.. - In: ACS APPLIED NANO MATERIALS. - ISSN 2574-0970. - 5:5(2022), pp. 6140-6148. [10.1021/acsanm.1c04365]

Quatsomes Formulated with l -Prolinol-Derived Surfactants as Antibacterial Nanocarriers of (+)-Usnic Acid with Antioxidant Activity

Galantini L.;
2022

Abstract

The efficacy of the treatment of bacterial infection is seriously reduced because of antibiotic resistance; thus, therapeutic solutions against drug-resistant microbes are necessary. Nanoparticle-based solutions are particularly promising for meeting this challenge because they can offer intrinsic antimicrobial activity and sustained drug release at the target site. Herein, we present a newly developed nanovesicle system of the quatsome family, composed of l-prolinol-derived surfactants and cholesterol, which has noticeable antibacterial activity even on Gram-negative strains, demonstrating great potential for the treatment of bacterial infections. We optimized the vesicle stability and antibacterial activity by tuning the surfactant chain length and headgroup charge (cationic or zwitterionic) and show that these quatsomes can furthermore serve as nanocarriers of pharmaceutical actives, demonstrated here by the encapsulation of (+)-usnic acid, a natural substance with many pharmacological properties.
2022
(+)-usnic acid; antibacterial activity; antioxidant activity; chemical structure-activity relationship; depressurization of an expanded liquid organic solution-suspension; l -prolinol-derived surfactants; nanovesicles; quatsomes
01 Pubblicazione su rivista::01a Articolo in rivista
Quatsomes Formulated with l -Prolinol-Derived Surfactants as Antibacterial Nanocarriers of (+)-Usnic Acid with Antioxidant Activity / Battista, S.; Kober, M.; Bellio, P.; Celenza, G.; Galantini, L.; Vargas-Nadal, G.; Fagnani, L.; Veciana, J.; Ventosa, N.; Giansanti, L.. - In: ACS APPLIED NANO MATERIALS. - ISSN 2574-0970. - 5:5(2022), pp. 6140-6148. [10.1021/acsanm.1c04365]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1661157
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