Bone pain typically occurs immediately following skeletal damage with mechanical distortion or rupture of nociceptive fibres. The pain mechanism is also associated with chronic pain conditions where the healing process is impaired. Any load impacting on the area of the fractured bone will stimulate the nociceptive response, necessitating rapid clinical intervention to relieve pain associated with the bone damage and appropriate mitigation of any processes involved with the loss of bone mass, muscle, and mobility and to prevent death. The following review has examined the mechanisms of pain associated with trauma or cancer-related skeletal damage focusing on new approaches for the development of innovative therapeutic interventions. In particular, the review highlights tissue engineering approaches that offer considerable promise in the appli- cation of functional biomimetic fabrication of bone and nerve tissues. The strategic combination of bone and nerve tissue engineered models provides significant potential to develop a new class of in vitro platforms, capable of replacing in vivo models and testing the safety and efficacy of novel drug treatments aimed at the resolution of bone-associated pain. To date, the field of bone pain research has centred on animal models, with a paucity of data correlating to the human physiological response. This review explores the evident gap in pain drug development research and suggests a step change in approach to harness tissue engineering technologies to recapitulate the complex pathophysiological environment of the damaged bone tissue enabling evaluation of the associated pain-mimicking mechanism with significant therapeutic potential therein for improved patient quality of life.

Modelling skeletal pain harnessing tissue engineering / Iafrate, Lucia; Benedetti, Maria Cristina; Donsante, Samantha; Rosa, Alessandro; Corsi, Alessandro; Oreffo, Richard O. C.; Riminucci, Mara; Ruocco, Giancarlo; Scognamiglio, Chiara; Cidonio, Gianluca. - In: IN VITRO MODELS. - ISSN 2731-3433. - 1:4-5(2022), pp. 289-307. [10.1007/s44164-022-00028-7]

Modelling skeletal pain harnessing tissue engineering

Benedetti, Maria Cristina;Donsante, Samantha;Rosa, Alessandro;Corsi, Alessandro;Riminucci, Mara;Ruocco, Giancarlo;Scognamiglio, Chiara;
2022

Abstract

Bone pain typically occurs immediately following skeletal damage with mechanical distortion or rupture of nociceptive fibres. The pain mechanism is also associated with chronic pain conditions where the healing process is impaired. Any load impacting on the area of the fractured bone will stimulate the nociceptive response, necessitating rapid clinical intervention to relieve pain associated with the bone damage and appropriate mitigation of any processes involved with the loss of bone mass, muscle, and mobility and to prevent death. The following review has examined the mechanisms of pain associated with trauma or cancer-related skeletal damage focusing on new approaches for the development of innovative therapeutic interventions. In particular, the review highlights tissue engineering approaches that offer considerable promise in the appli- cation of functional biomimetic fabrication of bone and nerve tissues. The strategic combination of bone and nerve tissue engineered models provides significant potential to develop a new class of in vitro platforms, capable of replacing in vivo models and testing the safety and efficacy of novel drug treatments aimed at the resolution of bone-associated pain. To date, the field of bone pain research has centred on animal models, with a paucity of data correlating to the human physiological response. This review explores the evident gap in pain drug development research and suggests a step change in approach to harness tissue engineering technologies to recapitulate the complex pathophysiological environment of the damaged bone tissue enabling evaluation of the associated pain-mimicking mechanism with significant therapeutic potential therein for improved patient quality of life.
2022
Bone pain, In vitro models, Fracture, Nerve, Bone cancer
01 Pubblicazione su rivista::01a Articolo in rivista
Modelling skeletal pain harnessing tissue engineering / Iafrate, Lucia; Benedetti, Maria Cristina; Donsante, Samantha; Rosa, Alessandro; Corsi, Alessandro; Oreffo, Richard O. C.; Riminucci, Mara; Ruocco, Giancarlo; Scognamiglio, Chiara; Cidonio, Gianluca. - In: IN VITRO MODELS. - ISSN 2731-3433. - 1:4-5(2022), pp. 289-307. [10.1007/s44164-022-00028-7]
File allegati a questo prodotto
File Dimensione Formato  
Iafrate_Modelling_2022.pdf

accesso aperto

Tipologia: Documento in Post-print (versione successiva alla peer review e accettata per la pubblicazione)
Licenza: Creative commons
Dimensione 3.8 MB
Formato Adobe PDF
3.8 MB Adobe PDF

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1660709
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact