The regulation of cerebral blood flow (CBF) is a complex and tightly controlled function ensuring delivery of oxygen and nutrients and removal of metabolic wastes from brain tissue. Cerebral vasoreactivity (CVR) refers to the ability of the nervous system to regulate CBF according to metabolic demands or changes in the microenvironment. This can be assessed through a variety of nuclear medicine and imaging techniques and protocols. Several studies have investigated the association of CVR with physiological and pathological conditions, with particular reference to the relationship with cognitive impairment and cerebrovascular disorders (CVD). A better understanding of the interaction between CVR and cognitive dysfunction in chronic and particularly acute CVD could help improving treatment and rehabilitation strategies in these patients. In this paper, we reviewed current knowledge on CVR alterations in the context of acute and chronic CVD and cognitive dysfunction. Alterations in CVR and hemodynamics have been described in patients with both neurodegenerative and vascular cognitive impairment, and the severity of these alterations seems to correlate with CVR derailment. Furthermore, an increased risk of cognitive impairment progression has been associated with alterations in CVR parameters and hemodynamics. Few studies have investigated these associations in acute cerebrovascular disorders and the results are inconsistent; thus, further research on this topic is encouraged.

The impact of cerebral vasomotor reactivity on cerebrovascular diseases and cognitive impairment / Sforza, Michela; Bianchini, Edoardo; Alivernini, Diletta; Salvetti, Marco; Pontieri, Francesco E; Sette, Giuliano. - In: JOURNAL OF NEURAL TRANSMISSION. - ISSN 0300-9564. - 129:11(2022), pp. 1321-1330. [10.1007/s00702-022-02546-w]

The impact of cerebral vasomotor reactivity on cerebrovascular diseases and cognitive impairment

Sforza, Michela
Primo
;
Bianchini, Edoardo
Secondo
;
Alivernini, Diletta;Salvetti, Marco;Pontieri, Francesco E;Sette, Giuliano
2022

Abstract

The regulation of cerebral blood flow (CBF) is a complex and tightly controlled function ensuring delivery of oxygen and nutrients and removal of metabolic wastes from brain tissue. Cerebral vasoreactivity (CVR) refers to the ability of the nervous system to regulate CBF according to metabolic demands or changes in the microenvironment. This can be assessed through a variety of nuclear medicine and imaging techniques and protocols. Several studies have investigated the association of CVR with physiological and pathological conditions, with particular reference to the relationship with cognitive impairment and cerebrovascular disorders (CVD). A better understanding of the interaction between CVR and cognitive dysfunction in chronic and particularly acute CVD could help improving treatment and rehabilitation strategies in these patients. In this paper, we reviewed current knowledge on CVR alterations in the context of acute and chronic CVD and cognitive dysfunction. Alterations in CVR and hemodynamics have been described in patients with both neurodegenerative and vascular cognitive impairment, and the severity of these alterations seems to correlate with CVR derailment. Furthermore, an increased risk of cognitive impairment progression has been associated with alterations in CVR parameters and hemodynamics. Few studies have investigated these associations in acute cerebrovascular disorders and the results are inconsistent; thus, further research on this topic is encouraged.
2022
Cerebral vasoreactivity; Cerebrovascular disorders; Cognitive dysfunction; Stroke; Brain; Cerebrovascular Circulation; Humans; Magnetic Resonance Imaging; Oxygen; Cerebrovascular Disorders; Cognitive Dysfunction
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
The impact of cerebral vasomotor reactivity on cerebrovascular diseases and cognitive impairment / Sforza, Michela; Bianchini, Edoardo; Alivernini, Diletta; Salvetti, Marco; Pontieri, Francesco E; Sette, Giuliano. - In: JOURNAL OF NEURAL TRANSMISSION. - ISSN 0300-9564. - 129:11(2022), pp. 1321-1330. [10.1007/s00702-022-02546-w]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1660529
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