B-type natriuretic peptide (BNP) is a diagnostic and prognostic marker in heart failure (CHF) patients. Aim. To assess the relation between BNP, diastolic function and exercise capacity in CHF patients. Methods. Fifty CHF patients underwent cardiopulmonary exercise testing. BNP levels were determined at baseline and at peak exercise. Patients were divided in two groups: with lower (14 ml/kg/min) or higher (14 ml/kg/min) peak oxygen consumption (VO2). Results. Seventeen patients with lower peak VO2 showed larger incidence of restrictive pattern of the transmitral flow (7/17 vs 4/33, p =0.036). E/Ea ratio was inversely related with peak VO2 (r =-0.419, p =0.004) and directly related with BNP levels at baseline (r =0.449, p =0.001) and at peak exercise (r =0.475, p =0.001). LV ejection fraction was similar in the two groups. Independent predictors of exercise tolerance were E/Ea ratio (p =0.003), lg BNP at baseline (p =0.034) and increase in lg BNP during exercise (p =0.038). Conclusions. In CHF patients, E/Ea ratio is a predictor of exercise tolerance and is related with BNP level at rest and at peak exercise.
Diastolic function and BNP changes during exercise predict oxygen consumption in chronic heart failure patients / Ciampi, Q; Borzillo, G; Barbato, E; Petruzziello, B; Betocchi, S; Villari, B. - In: SCANDINAVIAN CARDIOVASCULAR JOURNAL. - ISSN 1401-7431. - 43:1(2009), pp. 17-23. [10.1080/14017430802175720]
Diastolic function and BNP changes during exercise predict oxygen consumption in chronic heart failure patients
Barbato E;
2009
Abstract
B-type natriuretic peptide (BNP) is a diagnostic and prognostic marker in heart failure (CHF) patients. Aim. To assess the relation between BNP, diastolic function and exercise capacity in CHF patients. Methods. Fifty CHF patients underwent cardiopulmonary exercise testing. BNP levels were determined at baseline and at peak exercise. Patients were divided in two groups: with lower (14 ml/kg/min) or higher (14 ml/kg/min) peak oxygen consumption (VO2). Results. Seventeen patients with lower peak VO2 showed larger incidence of restrictive pattern of the transmitral flow (7/17 vs 4/33, p =0.036). E/Ea ratio was inversely related with peak VO2 (r =-0.419, p =0.004) and directly related with BNP levels at baseline (r =0.449, p =0.001) and at peak exercise (r =0.475, p =0.001). LV ejection fraction was similar in the two groups. Independent predictors of exercise tolerance were E/Ea ratio (p =0.003), lg BNP at baseline (p =0.034) and increase in lg BNP during exercise (p =0.038). Conclusions. In CHF patients, E/Ea ratio is a predictor of exercise tolerance and is related with BNP level at rest and at peak exercise.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.