Since the first report on biventricular pacing in 1994, cardiac resynchronization therapy (CRT) has become standard for patients with advanced heart failure (HF) and ventricular conduction delay. CRT improves myocardial function by resynchronizing myocardial contraction, which results in reverse left ventricular remodeling and improves symptoms and clinical outcomes. Despite the accelerated development of CRT device technology and its increased application in treating HF patients, almost one-third of these patients do not respond to the therapy or gain any clinical benefit from device implantation. Over the last decade, multiple cardiac imaging modalities have provided a deeper understanding of myocardial pathophysiology, thereby improving HF treatment management. However, the optimal strategy for improving the CRT response remains debatable. This article provides an updated overview of the electropathophysiology of myocardial dysfunction in ventricular conduction delay and the diagnostic approaches involving the use of multiple modalities.

Cardiac Resynchronization Therapy Optimization: A Comprehensive Approach / Katbeh, A.; Van Camp, G.; Barbato, E.; Galderisi, M.; Trimarco, B.; Bartunek, J.; Vanderheyden, M.; Penicka, M.. - In: CARDIOLOGY. - ISSN 0008-6312. - 142:2(2019), pp. 116-127. [10.1159/000499192]

Cardiac Resynchronization Therapy Optimization: A Comprehensive Approach

Barbato E.;
2019

Abstract

Since the first report on biventricular pacing in 1994, cardiac resynchronization therapy (CRT) has become standard for patients with advanced heart failure (HF) and ventricular conduction delay. CRT improves myocardial function by resynchronizing myocardial contraction, which results in reverse left ventricular remodeling and improves symptoms and clinical outcomes. Despite the accelerated development of CRT device technology and its increased application in treating HF patients, almost one-third of these patients do not respond to the therapy or gain any clinical benefit from device implantation. Over the last decade, multiple cardiac imaging modalities have provided a deeper understanding of myocardial pathophysiology, thereby improving HF treatment management. However, the optimal strategy for improving the CRT response remains debatable. This article provides an updated overview of the electropathophysiology of myocardial dysfunction in ventricular conduction delay and the diagnostic approaches involving the use of multiple modalities.
2019
Cardiac dyssynchrony; Cardiac resynchronization; Heart failure; Myocardial dysfunction; Therapy optimization; Cardiac Resynchronization Therapy; Cardiac Resynchronization Therapy Devices; Echocardiography; Heart Failure; Heart Ventricles; Humans; Myocardial Contraction; Patient Selection; Stroke Volume; Ventricular Dysfunction; Left; Ventricular Remodeling
01 Pubblicazione su rivista::01a Articolo in rivista
Cardiac Resynchronization Therapy Optimization: A Comprehensive Approach / Katbeh, A.; Van Camp, G.; Barbato, E.; Galderisi, M.; Trimarco, B.; Bartunek, J.; Vanderheyden, M.; Penicka, M.. - In: CARDIOLOGY. - ISSN 0008-6312. - 142:2(2019), pp. 116-127. [10.1159/000499192]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1659162
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